Have you ever wondered,why your blood sugar remains unmanaged, despite taking a lot of medication ? It is time to think and understand.

[patliputra]

The type2 diabetes is the most common form of diabetes comprising more than 90% of all diabetics.

The primary events in type 2 are believed to be an initial insensitivity of insulin resulting in peripheral insulin resistance and later on , relative insulin deficiency .

The important point is that major cellular dysfunction that occurs in type2 diabetes is NOT due to Beta cells of pancreas, it is due to the muscle, fat and liver cells and to some extent red blood cells due to glycation. However over a period of YEARS beta cell dysfunction can occur with type2 diabetes.

So, the beta cell dysfunction is not the primary issue with type2 diabetes. The key cells affected when type2 diabetes initially develop ( due to hyperinsulinemia ), include glycated red blood cells,muscle, fat and liver cells,which are designed toto take glucose out of blood and pull it into cells and change it into energy.

Those cells require insulin to absorb glucose. When these cells fail to respond adequately to circulating insulin,these cells loose their sensitivity to insulin ( insulin resistance ), and blood glucose level rise.

The body responds to this situation by signalling pancreas to produce more insulin, causing insulin level in blood to become too high ( hyperinsulinemia ) . The cells of liver become insulin resistant and respond by making too much blood sugar. Because sugar in blood is not absorbed by the cells, it stays in the blood, causing blood sugar to rise (hyperglycaemia ).

Given the cellular dysfunction of muscle cells,fat cells and liver cells,majority of diabetic drugs are not going to help in reducing blood sugar or reversing the diabetes. As majority of anti diabetic drugs are designed either to make pancreas secrete more insulin or prevent liver from releasing stored glycogen. The drugs do nothing to address the insulin resistance of muscle cells and fat cells or the the inflammatory damage caused by coarse glycated red blood cells.

It was an attempt to understand why many times drug treatment fails in cases of type2 diabetes.

[klgksharma]

But i remember to have read somewhere that the duty of METFOMIN is to make the cells absorb insulin ?

Based on your write up if the doctors do not address the cause properly and prescribe insulin secreting drugs, it is more dangerous than being diabetic as the insulin level will shoot up.

[patliputra in reply to klgksharma]

You are right. Metformin increases the sensitivity of muscle,fat and liver cells to insulin.that is why I said majority of drugs and not all drugs.

As for your second part , that is why there is failure of treatment in early stages of development of diabetes type2.

[Hidden]

All TD2 specially occur due to metabolism disorder and the basic reason is vitamin D3 deficiency for which no one taking care almost 100 % and no doctor or a few has suggested vitamin d3 deficiency only they are interested to see pp and Fbps + and Hb1ac which requires for maintenance medication but not for prevention.

My request to all should go for vitamin d3 deficiency test first then go for other tests to decide medication if we can maintain Vitamin D3 optimum level 60-to 70 units then all medication , Yoga, Pranayama, Diet will work more effiently even initial stage sufferers may got reverse it and who are non diabetic will be remain non diabetic by maintaining optimum level of Vitamin d3 in body.

[patliputra in reply to Hidden]

I agree life style changes can be effective in controlling blood sugar and also reversing diabetes in pre diabetic stage.

[patliputra in reply to Hidden]

Vit D deficiency as risk factor for metabolic syndrome is yet to be proved. At the same time it is more prevalent in developed and not in under developed countries.

[patliputra]

I tried to present an overall picture , why there is treatment failure in early stages of disease. Indivisual drugs were not discussed. As far as pioglitazone is concerned,it does try to over come insulin resistance ,acting as insulin receptor . But all are aware about AVENDIA, same group of drug. So safety issues are there specially in cardiac patients.

[patliputra]

I compliment you for asking a very pertinent question.

[Hidden]

Dear Patliputra if you are pure diabetic then your vitamin d3 level must be 50-60 and apparent diabetic the vitamin d3 level will be below 30 test it and then see it. but continuous apparent diabetic are suppose to be pure and permanent diabetic after a long time.

[patliputra]

Dear basudev, though I am not familiar with pure or apparent diabetes. I take that it means full fleged diabetes and pre diabetic.

Next time when I go for routine blood chemistry , I will include Vit D.

BTW I am pure diabetic.

[patliputra]

Pre diabetes is internationally recognised term.

11 a to 3 pm is ideal time to get uv rays and even an hours exposure to sun light will provide more than required Vit D. The only condition is you should be without sun screen .😀

[Hidden in reply to patliputra]

The most of diabetic persons does not doing walk or excersice it ? Is vit D is main cause of DM By natural way vit D is not sufficinet ?

[patliputra in reply to Hidden]

People have become very health conscious . Excercise and walking has become very common.

[patliputra]

An association has been seen between hyperglycaemia and low levels of Vit D in older people. But how far it is applicable in our climate is is very difficult to say.

[patliputra]

I may differ from your view point, and I believe there is a twilight zone between diabetic and non diabetic,the pre diabetes.

[Hidden in reply to patliputra]

In Indian whether anywhere if we going walk on sun raising period either outside or stairs of our house at least halfonhour it may be sufficient

[patliputra in reply to Hidden]

Please note that uv rays are not present during morning or late afternoon. Maximum availability is between 11am and 3pm.

[Hidden]

Vit D is short the persons bed ridden and not able to walk out door or any way then vit D must be used

[patliputra]

It is becoming habit to remain indoors during working hours. Even elder people avoid sun due to variable reasons.

[patliputra in reply to patliputra]

Special cases require special treatment.

[patliputra]

But it will come down to non diabetic level within 2 hours.

[patliputra]

Exactly right.

[patliputra]

You have your logic but our discussion is shifting, as it will entail what is normal non diabetic bs and so on and so forth .so, please postpone it for some other time. Thanks.