A fat is the cause of type 2 diabetes

What if there’s enough insulin, but the insulin doesn’t work? The key is there, but something’s gummed up the lock. This is insulin resistance. Our muscle cells become resistant to the effect of insulin. What’s gumming up the locks on our muscle cells? What’s preventing insulin from letting glucose in? Tiny droplets of fat inside our muscle cells, so-called intramyocellular lipid.

Fat in the bloodstream can build up inside the muscle cell, creating toxic fatty breakdown products and free radicals that block the insulin signaling process. No matter how much insulin we have in our blood, it’s not able to sufficiently open the glucose gates and blood sugar levels build up in the blood. And this can happen within three hours. One hit of fat can start causing insulin resistance, inhibiting blood sugar uptake after just 160 minutes.

This mechanism by which fat induces insulin resistance wasn’t known until fancy MRI techniques were developed to see what was happening inside people’s muscles as fat was infused into their bloodstream. That’s how we found that elevation of fat levels in the blood causes insulin resistance by inhibition of glucose transport into the muscles.

We can also do the opposite experiment. Lower the level of fat in people’s blood and the insulin resistance comes right down. If we clear the fat out of the blood, we also clear the sugar out. That explains the finding that on the high fat, ketogenic diet, insulin doesn’t work very well. Our bodies become insulin resistant. But as the amount of fat in our diet gets lower and lower, insulin works better and better—a clear demonstration that the sugar tolerance of even healthy individuals can be impaired by administering a low-carb, high-fat diet. We can decrease insulin resistance, however, by decreasing fat intake.



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12 Replies

  • How much is high fat and How much is low fat?

  • High fat is around 60% good healthy fats in the form of nuts, dairy items like milk, curd, cheese, paneer etc, butter and ghee...some uses VCO in place of vegetable oils we use for cooking when one follows LCHF (Low carbs High Fat diet)

    Low fat meaning 20% of total calories taken.

  • Gummed up is a typical VEGANS explanation.

    Insulin is the key. Reduce that and all gumming up is gone forever. Many like me have been eating all the saturated fat and yet have far better numbers than what a VEGAN could ever achieve despite eating twice the amount of fiber than what we eat on 20% carbs a day.

  • I know once diabetes occurs, high good fat in diet would help control numbers but basically how an IR is caused? I think it is fat...bad fat you may call it.

    You haven't measure your IR so far...right? So, you don't know how much insulin resistant you are comparatively than when you were diagnosed with D. Here, in this article, it is said high fat ketogenic diet is not good for insulin response...that's why may be all keto diet followers say to reduce insulin by doing IF. Is that the only way out for diabetics then?

    I see my numbers more after breakfast than after lunch eating the same food. So, I think basically we all have first phase insulin lost problem... which I haven't understood yet properly ...which may be causing high blood sugar spikes after first time we eat in a day whether it is morning or noon by eating same food. Even Medicines taken before breakfast doesn't control PPBS spikes after first time we eat in a day after a long night's fast even though FBS is well below 100 mg/dl

  • I know once diabetes occurs, high good fat in diet would help control numbers but basically how an IR is caused?

    HIGH CARBS leads to IR.

    First phase insulin response conked off, I have mentioned many times. Not just first time but any time one eats.

  • What causes bad (visceral) fat? Too much fructose/alcohol.

    Also, it's a vicious cycle. High insulin levels promote fat storage, gums up the works, causes insulin resistance causes chronic high insulin levels. What initiates high insulin levels? High glycaemic foods and/or anomalies such as fruit yoghurt or baked beans.

  • @Ashka9

    not mentioned how long before the study was undertaken. It's looking at the issues from wrong end. Also what kinds of fats increases IR is not mentioned. Lipogenesis is caused by insulin and low insulin levels causes lipolysis. So if you want to lose fats/ weight you have to cut down carbs intake which in turn would cause insulin levels to fall. Fats have zero effect on insulin. So howmuchsoever fats you eat it can't be stored in our body. And the kind of fat that we are advocating is mct and sct which are soon metabolised in the liver and stored as atp and not as fats. The fats that are stored in the body are lcts like palmitic acid. If you know that there is any mechanism in our body that converts scts and mcts to lcts let us all know.

  • nutritionfacts.org is a Vegan's site -- Greger is a Vegan proponent -- eat just plant food and nothing else. They don't like fat so offer this weird "gumming" effect as they are anti fat per se'. They restrict it more by removing all animal fat including dairy.

  • @Anup

    There should be scientific facts behind the arguments one does.

  • Greger (of nutritionfacts.org) even relies on some study done by Dr. Richard Fleming who himself has been convicted of serial medical frauds.


  • The poor fools!

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