Supplement Cocktail is working (Massive B1 OD) or is it the Fatty15

[Gcf51]

5/8/24: I am one of two PwP (that I know of) that are taking Fatty15. They have never found their B1 sweet-spot. They are lowering their B1 dose in hopes of finding their sweet-spot. I started lowering my dose of B1 on day 15 of taking Fatty15.

There is a good possibility that Fatty15 is responsible for us having to lower our B1 dose.

Maybe all the Hype on Fatty15's website isn't just Hype? fatty15.com/

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A continuation of “Trying too many supplements at the same time. Maybe crying wolf. It’s really too early to tell”. (Last meaningful edit 4/19/24) healthunlocked.com/cure-par...

First a question for               Dap1948 : What is the contingency plan for those on “B1 Therapy”, that have found their sweet-spot, if they have return of symptoms because something might be working?

My answer: Take a B1 Break… And start back, after the break, at a lower dose.

On 4/20/24 Text I sent a friend: “I am fighting the urge to take a small dose of TTFD. Alinamin F (TTFD) is a prescription drug in Japan and prescribed for fatigue. It is also a thiol-containing compound. Thiols can treat the toxic effects of Levodopa overdose*. Symptoms of overdose may include: severe dizziness, irregular heartbeat, mental/mood changes (such as agitation). I got by taking 2-1/2 extra levodopas last week (for the dance) with no symptoms of overdose. I am now on Day 8 of a B1 Break, so a small dose should not cause a B1 overdose, but TTFD crosses the BBB… >> For some extra energy, maybe avoidance of Levodopa overdose and considering the B1 break; a small dose of Alinamin (F) should not cause a B1 overdose. << I gave in and took a half of a 5mg tablet. 2-1/2mg TTFD (1.66mg B1) is still 1-1/2 times the daily recommended allowance of B1.”

On 4/21/24 I sent a friend: “One of the symptoms of B1 OD is anxiety. I think most of that 1.7 mg went to my head. WOW, Fast heart beat and anxiety – really bad. It took over an hour to calm down.”

On 4/26/24 Started Inulin and Probiotics as mentioned in Art’s post healthunlocked.com/cure-par...

On 5/21/24 I sent a friend: “I had a massive return of symptoms yesterday – Parkinson’s like I have never experienced before. I had gone… to eat and went shopping. I made it home safe and survived going to bed. On second thought, I should have called someone to come pick me up. Something is happening for me to overdose on 750mg of B1 after only 4 days. Something as in supplements I am trying (or combo of)… I am feeling great today…” (I was on 925mg before the break.)

I have stated this before: I don’t like the term OD; Return of symptoms is nothing to fear; it’s only return of symptoms. Well… that was massive and maybe you should fear.

I am still taking 5-1/2 C/L a day. It’s going to be disappointing if I can’t reduce C/L and all I have done is reduce my B1 sweet-spot. I am praying it does more than B1 and I can get off C/L.

I have written Mitopure asking what makes their product better than others. Their reply, High Quality Urolithin A — I am going to switch to a cheaper brand.

Disclaimer: I am willing to take risks with my health and possibly waste my money – I don’t recommend that anybody do what I have done. Do your Research, talk with your Doctor, weigh the cost and then make your own decision.

I don’t recommend TTFD (thiamine tetrahydrofurfuryl disulfide). I was unable to find my sweet-spot with TTFD – I got tired of ODing on yet another lower dose.

I take entirely too many supplement and need to weed out some. I have reduced PEA back to 1/2 recommended dose.

* (added after posting) There is an error in this statement. A google search reveals: “Such toxic effects of levodopa can be blocked by co-treatment with antioxidants, particularly thiol-containing compounds.” But further reading indicates “in vitro” levodopa is toxic — studies in living tissue indicate it is nontoxic. The words "overdose and treat" should not have been used.

[Gcf51]

Edited Added: * (added after posting) There is an error in this statement. A google search reveals: “Such toxic effects of levodopa can be blocked by co-treatment with antioxidants, particularly thiol-containing compounds.” But further reading indicates “in vitro” levodopa is toxic — studies in living tissue indicate it is nontoxic. The words "overdose and treat" should not have been used.

Changed Title to is working.

[Gcf51 in reply to Gcf51]

In recent post healthunlocked.com/cure-par...

The linked art indicates: "Studies have shown that levodopa toxicity can damage neuronal cells. The formation of free radicals once the body oxidizes levodopa can induce apoptosis. Also, dopamine, norepinephrine, and epinephrine levels can rise in the blood when levodopa undergoes decarboxylation in the periphery. The rise in catecholamines activates alpha and beta-adrenergic receptors and results in toxic effects."

So maybe I didn't error. Google AI did....

But, there's no mention of treatment for toxicity of l-dopa.

What are the symptoms of high catecholamines? << The release of catecholamines can cause persistent or episodic high blood pressure, headache, sweating and other symptoms. If left untreated, a pheochromocytoma can result in severe or life-threatening damage to other body systems, especially the cardiovascular system.

[Gcf51]

I am one of two PWP (that I know of) that are taking Fatty15. They have never found their B1 sweet-spot. They are lowering their dose in hopes of finding their sweet-spot. I started lowering my dose of B1 on day 15 of taking Fatty15.

There is a good possibility that Fatty15 is responsible for us having to lower our B1.

Maybe all the Hype on Fatty15's website isn't just Hype? fatty15.com/

[Gcf51]

I like Brain Storming – throwing out wild ideas and seeing what comes back.

If you have tried Fatty15 and had a bad reaction; maybe, it wasn’t the Fatty15; maybe, it’s the Fatty15 and B1 working together. Maybe you should have taken a B1 break. Maybe you need some B1 in your brain.

I know, I said I don't endorse TTFD, but it is the fastest way to get B1 to the brain.

I ordered my Alinamin-F (TTFD) from (now sold out) They wouldn't take my card and I had to send a wire transfer. mimaki-family-japan.com/ite...

The 1/2 tab of 5mg Alinamin F took less than an hour to OD. The 750mg B1 hcl oral took 4 days.

Please excuse me, I am on a roll with wild ideas....

[Gcf51]

Since starting Fatty15 (78 days ago), I have took 26 days of B1 breaks. I am currently on day 5 of a B1 break.

[Mezmerric]

I found this on C:15 which is interesting - but the author is employed by the supplement company so it would be good to find other studies.

Pentadecanoic acid (C15:0) is an essential odd-chain saturated fatty acid with broad activities relevant to protecting cardiometabolic, immune, and liver health. C15:0 activates AMPK and inhibits mTOR, both of which are core components of the human longevity pathway. To assess the potential for C15:0 to enhance processes associated with longevity and healthspan, we used human cell-based molecular phenotyping assays to compare C15:0 with three longevity-enhancing candidates: acarbose, metformin, and rapamycin. C15:0 (n = 36 activities in 10 of 12 cell systems) and rapamycin (n = 32 activities in 12 of 12 systems) had the most clinically relevant, dose-dependent activities. At their optimal doses, C15:0 (17 µM) and rapamycin (9 µM) shared 24 activities across 10 cell systems, including anti-inflammatory (e.g., lowered MCP-1, TNFα, IL-10, IL-17A/F), antifibrotic, and anticancer activities, which are further supported by previously published in vitro and in vivo studies. Paired with prior demonstrated abilities for C15:0 to target longevity pathways, hallmarks of aging, aging rate biomarkers, and core components of type 2 diabetes, heart disease, cancer, and nonalcoholic fatty liver disease, our results support C15:0 as an essential nutrient with activities equivalent to, or surpassing, leading longevity-enhancing candidate compounds.

[Mezmerric in reply to Mezmerric]

As a follow up post Rapamycin is very well studied, so might be a better option than C:15

[Gcf51 in reply to Mezmerric]

I agree everything about Fatty15 is by the officers/patent holders of Fatty15 and is therefore bias.

More on subject: healthunlocked.com/cure-par...

[Gcf51 in reply to Mezmerric]

Is Rapamycin the same as Fatty15 (Pentadecanoic acid (C15:0))?

Brand names for sirolimus include Rapamune. The cost for sirolimus oral tablet 1 mg is around $240 for a supply of 30 tablets, depending on the pharmacy you visit. At 240 fatty15 is less, but insurance may pay for Rapamune.

[Mezmerric in reply to Gcf51]

No. Rapamycin is a fungus discovered on Easter Island and turned into a drug that is prescribed as a immunosuppressant. It has then been found to have longevity benefits and many people take it off label. It is well researched. C:15 is claiming to have similar benefits which is why the author of C:15 is comparing it with Rapamycin.

[Mezmerric in reply to Gcf51]

A link to recent research on Rapamycin and Parkinsons.

hopkinsmedicine.org/news/ne...

[Gcf51 in reply to Mezmerric]

Thanks,

[Gcf51]

I accidently missed a dose of C/L. When I realized, I had eaten a meal. I took 4 hours late and I only had a very slight tremor.

[Gcf51]

In a private message (Chat) someone wrote:

In a healthy gut, the microbiome is able to produce enough thiamine for the bodies needs :

ncbi.nlm.nih.gov/pmc/articl...

Here is a relevant quote :

' Among gut microbes, approximately half encode the enzymes for de novo thiamine synthesis [3]. This synthesis includes production of the precursors thiazole and hydroxymethyl pyrimidine followed by the combination of these precursors into thiamine [4]. '

If half of the gut microbes have the capability to produce thiamine then it suggests that the gut microbiome is not only capable of producing sufficient thiamine, but it likely means that the body has a multitude of uses for thiamine.

The author -- I consider very reliable

Now… Could my ODs be due to my gut is now producing all the B1 my body needs.

[Gcf51]

Technically, I have ended my B1 break: For the last 4 days, I have been taking 1/4tab of a 5mg Alinamin F (1.25mg of TTFD is 70% RDA for B1, see pic).

Cal's