I gave up on TTFD (thiamine tetrahydrofurfuryl disulfide - a B1 derivative) because; I would settle in on a sweet-spot, within a few weeks I would overdose, I lowered my dose and repeated again & again. Thinking maybe that wouldn’t be a bad thing — could it be a cure and would I get down to just recommended B1 or less? I may never know, for me I settled on my sweet-spot of 1000mg B1 hcl oral. But! I would love to see a Clinical Trial on it.
Not an endorsement for TTFD — needs research....
I am a firm believer that High Dose Thiamine (HDT) works.