Hats off to sunvox for having mentioned Trehalose a few times in these forums healthunlocked.com/ataxia-u...
I did my own searching and found Trehalose as a promising therapeutic candidate for the treatment of Parkinson's disease - 2019 ncbi.nlm.nih.gov/pmc/articl...
Neuroprotective Effects of Trehalose and Sodium Butyrate on Preformed Fibrillar Form of α-Synuclein-Induced Rat Model of Parkinson’s Disease - 2021 pubs.acs.org/doi/10.1021/ac...
I did find this article "Natural Compounds and Autophagy: Allies Against Neurodegeneration" frontiersin.org/articles/10... from 2020 that says you can't take Trehalose orally, but that confuses me because sunvox linked to ncbi.nlm.nih.gov/pmc/articl... seems to indicate taking 100 grams a day does make it into your blood.
There is also this article from 2017 Autophagy induction by trehalose: Molecular mechanisms and therapeutic impacts researchgate.net/publicatio... if you scroll down past the abstract it shows a bunch of citations with cool factoids.
Looks like I will be adding to my smoothie.
On the other hand, there is this :
sciencealert.com/common-sup...
sciencealert.com/common-sup....
cbc.ca/radio/quirks/how-an-...
bottomlineinc.com/health/di...
Art
Yikes! I thought I'd found the magic bullet
Well, at least if you get C.diff you are in line for poop pills.
WHEN TO AVOID TREHALOSE
For most people most of the time, there’s no need to avoid foods containing trehalose. Under normal circumstances, helpful bacteria in your gut outcompete C. diff, preventing illness.
But a great danger exists when you have a serious infection treated with “broad-spectrum” antibiotics, especially the kind that is serious enough to land you in the hospital. Those antibiotics wipe out helpful gut bacteria. Take action: Read ingredients lists on all packaged foods you eat, and avoid any that include trehalose while you are taking such antibiotics and for several weeks afterward. And avoid trehalose if you have or have recently recovered from a C. diff infection.
It seems like it may pose a hazard whenever gut dysbiosis is present because that is when it could potentially have a better chance to feed pathogenic bacteria associated with C-Diff. I think it is these super C. Diff. infections where FMT can shine and do its thing to try and regain control and shift the microbiota back toward health promoting bacteria. FMT seems to be a last resort measure in such cases where everything else has failed to stop C- Diff.
Art
A year ago, when I was new to all this, a reputable func med doc recommended 1 teaspoon a day of Trehalose. PB and I recently had a post / message stream about this. His research states that that is a pointless volume. I understand that for the purpose of autophagy / protein removal it is. So then why did the func med recommend 1 teaspoon? I fail to see the point. I don’t want to pay for another session especially if it was bad advice.
Because bears like blueberries if you eat blueberries does not mean a bear is going to attack you. The only way one is going to get C. Diff is by going to a nursing home and hanging out with old folks that have it. Eating trehalose will do nothing to reduce or increase your chances of contracting C. Diff. You're a smart guy Art; not sure why you would go down the scare tactic route for something that is used in food manufacturing and has a loooong history of safety in humans AND MIGHT just MIGHT help people with Parkinsons or other neurological disorders when there is virtually NOTHING the medical community has to offer that can slow progression of such diseases. Even IF you want to believe that somehow there is a risk associated with trehalose I argue it is FAR outweighed by the potential benefit.
Glad to see you back, Joe, it has been a minute!
Well, if you eat that blueberry in front of a bear, you may have a problem! 😋
Not trying to scare anyone, just trying to show some of what has been seen as regards Trehalose. It seems that everything used for PD has some risk and this includes prescription meds such as C/L and popular supplements such as HDT. Even exercise has some risk involved such as falling while walking or losing your balance on a treadmill and falling off. Just swallowing a pill confers the risk of choking in a person who has swallowing issues as is sometimes seen in PwP. I think it is useful to know what the risks might be, before starting something. If the risk seems low enough then it may be worth testing, but if the perceived risk is too high for the individual, then maybe not.
I absolutely agree that the medical community has nothing to slow the disease process and if that is what you seek, then you will have to look elsewhere, such as this forum as one example.
I hope you share some of your newer findings, Joe!
Art
Sunvox, interesting position and rather reassuring. I hope you will return to elaborate and share what you do.
If you click on a persons name you find all they have ever posted, but you can also go to this link for current info:
longecity.org/forum/topic/1...