Levodopa and magnesium oxide

[johntPM]

Based on in vtro results and a n=1 case study:

"Levodopa and carbidopa are reported to be degraded by magnesium oxide (MgO), which is often used as a laxative for patients with Parkinson's disease (PD). Ascorbic acid (AsA) can stabilize levodopa and carbidopa solutions; however, the effect of AsA on the degradation of levodopa and carbidopa induced by MgO has not been fully investigated."

Ref: onlinelibrary.wiley.com/doi...

There seems to me to be a possibility of the following happening:

Magnesium oxide leads to less carbidopa, leads to less levodopa, leads to more constipation, leads to the patient taking more magnesium oxide, and so on.

Now let's be clear this is pure conjecture on my part, but it may go part of the way to explaining differences in the efficacy of a patient's drug regimen and differences between patients.

John

[park_bear]

Parkinson's constipation remedies discussed here:

healthunlocked.com/cure-par...

[Kevin51]

Good reason to switch to another form of Magnesium!

[Smittybear7]

I take a product called Magnesium Complex by natural creations it has magnesium orate magnesium citrate and magnesium glycinate. I take two capsules at night along with two capsules of super cal plus probiotic vitamin C and turmeric. I take it at least an hour apart from the Sinemet.

[Psalmody]

My neurologist recommended Neuro Mag Magnesium L-Threonate. I hope this is ok to take?

[slimweiss]

My HWP takes 3-4 magnesium oxide at night before bed usually 1-2 hours after his meds. It works great for him but it does make me wonder about his wearing off in the middle of the night. He usually needs his dose every 4 hours. I will read up on it.