So this is kind of confusing. Bottom line is Clioquinol might be able to treat PD. What is odd, one article mentions Iron Chelation as why it might work. The newest suggests that it could work through Zinc redistribution or chelation. One says Clioquinol impacts LRRK2. All the results seem positive, but the reasons seem to be all over the place.
(Iron chelation) Clioquinol improves motor and non-motor deficits in MPTP-induced monkey model of Parkinson’s disease through AKT/mTOR pathway 2020 ncbi.nlm.nih.gov/pmc/articl...
(Zinc distribution or Chelation) The zinc ionophore clioquinol reduces Parkinson’s disease patient-derived brain extracts-induced neurodegeneration 2022 assets.researchsquare.com/f...
Clioquinol Protects Against Cell Death in Parkinson’s Disease Models In Vivo and In Vitro 2009 link.springer.com/chapter/1...
Effects of Neonatal Iron Feeding and Chronic Clioquinol Administration on the Parkinsonian Human A53T Transgenic Mouse 2016 pubs.acs.org/doi/10.1021/ac...
(LRRK2) New method developed to target cause of Parkinson’s 2019 neurosciencenews.com/parkin...