“Apoptosis induced by MPP+ was ameliorated by NTZ in a dose-dependent manner. In vivo results demonstrated that oral administration of NTZ (50 mg/kg) in an acute MPTP mouse model of PD conferred significant protection against the loss of tyrosine hydroxylase (TH)-positive neurons of substantia nigra. Based on the above observations we believe that repurposing of NTZ for PD may offer therapeutic benefit.”
ncbi.nlm.nih.gov/pmc/articl...
The Role of Mitochondrial Uncoupling on Aging
NTZ???
I believe we are talking about nitazoxanide. Usually given for parasites. Especially giardia, a very very horrible critter; and cryptosporidium. It may have been identified for other things using the new artificial intelligence computer routines they are using to look into what drugs might be re-purposed or useful for diseases other than those they've been originally identified for, one of the very serious miracles of the advancing computer applications to disease and science.
Now this looks like it could be of significant value.
NTZ worked as pretreatment only. Failed when applied after toxic insult.
Per study link:
" In the therapeutic model, administration of NTZ post MPTP treatment could not significantly restore the TH* staining of SNPc or striatum to that of control values or 7th day post MPTP treatment. However, as compared with day 14 MPTP treatment, the TH staining in the SNPc and striatum was significantly restored in MPTP + NTZ [pretreatment] group. The above data clearly suggest that NTZ could not reverse the loss of TH-positive neurons but has the ability in delaying the death of existing dopamine neurons of SNPc (Fig. 7, B–E). The locomotor activity of the animals as measured by open field test reflected the above findings (Fig. 7F). MPTP-treated animals exhibited a time-dependent loss in the locomotor activity as compared with controls." [emphases added]
*TH: Tyrosine hydroxylase or tyrosine 3-monooxygenase is the enzyme responsible for catalyzing the conversion of the amino acid L-tyrosine to L-3,4-dihydroxyphenylalanine (L-DOPA)
I find mitochondrial uncoupling to be of great interest. That was just an example. Did you see the other link? Just realized I only linked an abstract. I will add to my post
I am spending some time this morning looking at trehalose which looks promising
Great! I have been using it for about a year now. I posted about it a long time ago but thought it’s worth re-share.
How much do you take?
How much trehalose do you take? Have you notice any benefits? Any side effects?
1 teaspoon to 1 tablespoon It’s yummy
I had originally hoped it was for autophagy but as elucidated above, I now realize that is likely not the case but it might be helping my gut biome.
No side effects. Tastes yummy.
Can not discern benefits bc I’m doing and taking so much.
Is this pd?
Does exercise help Pd ?
Help for PD
5-HTP in patients not taking Sinemet can worsen symptoms of PD
GV-971 For Alzheimer's Disease Now and PD Later Next Year....maybe
