Any downside for Apigenin?

[Fumaniron]

Any downside for Apigenin? studies looked promising for Parkinson's. Dr Huberman likes it for his sleep stack (with L-theonine & mag). It's discussed a lot on the urology forum, with varying effects on testosterone and estrogen, depending on what I read....Thanks!

[glenandgerry]

I don't know the answer to that one but am keen to find out as both me and my PWP are taking it. Maybe you could provide links to what you've read on the urology forum? Thanks.

[Bolt_Upright]

The Therapeutic Potential of Apigenin 2019 ncbi.nlm.nih.gov/pmc/articl...

5. Conclusions

Based on the in vitro and in vivo evidence reported here, apigenin, a natural bioactive flavone-type molecule, could play a key role in the prevention and treatment of emerging global health issues, highlighting once again the significant use of food components and/or plant compounds. Overall, it is very difficult to get general or unequivocal information regarding its prophylactic function within the human body, its bioavailability and bioactivity due to high inter-individual variability, and the several mechanisms of its biological actions affecting human health. The possibility that different components present in the supplemented mixtures can interact, generating antagonistic, synergistic, or additive effects, makes it difficult to predict the function, or to differentiate between prevention and therapy. The use of apigenin among patients under conventional pharmacological therapy should be carefully addressed, given the high likelihood of food‒drug interactions. There is a need to establish new and adequate cellular and animal models, which may, in turn, allow the design of more efficient and prevention-targeted clinical studies using apigenin and/or its derivatives as candidates for therapeutic drugs in the near future.

[Fumaniron]

healthunlocked.com/sensitiv...