What damages the Neurons? Is it hereditary or simply damaged genes passed down? What do chronic and degenerative diseases have in common? Inflammation, Damaged Cells, a lot of times its undermethylation of vitamins ( vitamins that are not used because of an enzyme malfunction that does not break the vitamins down to a useable form for the body) . Exp. Iron deficiency can be low ferritin(iron in blood) however non anemic iron deficiency (iron not found in bones) ( would only be found by say a bone marrow biopsy when looking for something else. Reveling depleted storage of the iron. How can this happen with normal iron ferritin showing on finger prick and even elevated red blood cells on blood tests.The MTHFR (enzyme) mutation has come into play with lots of these diseases. RLS ( restless leg syndrome) is usually caused by iron depletion in the bones or blood, b/c folate and B vitamins were not being absorbed because MTHFR enzyme is faulty and since they were NOT converted to a form the body can use they are expelled . The end result is excessive homocysteine (a mean an vicious inflammatory amino acid) which inflames the whole body. Is PD a result of the body not being able to expel toxins? What are the statistics for PD with MTHFR (undermethylation) As MTHFR is seen in more than 40% of the world population? We see this mutation largely present in Autistic people so we know this affects the brain also. Thoughts?
Digging Deeper into Neuron Valley - Cure Parkinson's
Digging Deeper into Neuron Valley
Seems potentially intriguing but you're not connecting with me and i guess you are also not connecting with most* members on this forum because the technical jargons is not expressed in layman's terms.
Advice: rewrite and repost expressing in more simplistic language. Terms you could express better are::
undermethylation ??
ferritin??
MTHFR??
non anemic iron...??
homocysteine ??
RLS ??
*well aware that some few here can grasp the depth of what you're on about but they are a minority. A few others also write like you but thats why mostly they have very few replies because (though they have good intentions) they don't connect with most members
Thank you I tried to clarify my question a little. I feel little is known about the risks with this mutation however I see it frequently in PD and lots of other diseases
where people are having degenerative symptoms mainly because of the build up of scar tissue from the inflammation caused by homocysteine (amino acid).
Thank you this is very interesting as my theory is somewhere there is a breakdown in the body as toxins build up the body is not able to expel them properly Thiamine or a combination of nutrients the body is lacking because a process has failed. Like with that of the MTHFR mutations. I feel SO much more research needs to be done in this area. Thank you for your suggestion I will look further into it.
Totally right tlane77.
A lot of research is done, but I have the feeling, they don't look enough at the causative factors. This is an interessant site of researcher who really try to explain in simple words some studies. And I believe him that the next 12 months some interesting trials are continued..........and so , a bit pity , we have to wait certainly more then 12 months to get results.........f.e. Biogen , Summit for stem cells , Innomedica and Talineuren , Mannitol , ISCO , ......
meanwhile I will keeping on saving my brain cells as much as possible, by not eating to much toxins ;;; simply said, difficult done...
scienceofparkinsons.com/201...
If you find you have PD and say do a 23&me health result upload the results to livewello.com for $20 or a site you can see your raw data. It will show you the MTHFR mutations and if your body has trouble getting rid of toxins due to this, then you have a starting point. Methylated Vitamins and folate you can now by at local health food stores that are already broken down and you can start healing the homocysteine ,with the guidance of a Functional Medicine doctor or holistic physician that is familiar with these mutations of course, homocysteine that has taken over and inflamed your whole system. Its not that you are not eating the right foods its that the MTHFR enzyme is faulty with the mutation and cannot break the vitamins down starting a snowball effect in the system.
Thank you very much for the info, tlane77. I just had a bunch of blood work done, including a look at vitamin levels, etc. at a cellular level. Results aren't all back yet, but my homosysteine level is high. My functional health doctor/chiropractor suggested that I take a supplement (Super Methyl-SP from Apex Energetics) with large concentrations of B12, Folate, B6, and Riboflavin, among other things. I am very intrigued by your theory and eager to learn what you are doing to combat methylation issues.
My mother in law has Parkinson’s she lives with us. I have Mast Cell Activation Disease, ( allergic to everything) ( I also have Peripheral neuropathy) and a few other connective tissue disorders. I found my was caused by this simple enzyme malfunction and my inflammation was so bad. Long story short my mother-in-law and I both Had MTHFR mutation We both had high homocysteine levels. We started on methylated vitamins with trimethylglycine. That’s it both of us couldn’t walk good for foot pain before now we can. We both had trouble choking on food now we are fine. I do believe it was a toxin build up and without the methylated vitamins our bodies were no able to cope and it was affecting our nervous systems. We were both raised on farms around pesticides the end result just could’ve taken different pathways is One theory.
this is very very interesting!
“we started on methylated vitamins with trimetylglycine”.
I could ask you what your exact protocol is and how long you use it. has the homocyssteine reduced? Given the remarkable result achieved I find this very interesting and I would like to apply it.
When I was young I used pesticides of all kinds, then I quit but now I have the PD. At that time I found the use of B3 vitamin niacin (NA) to be very useful at high doses for short periods to detoxify.
Thank you Gio
I do have one copy of the mthfr gene what do you suggest? I avoid folic acid, should I take folate ? When I ask my drs they seemed stumped. I only found out because of bloodwork done during a pregnancy. Would a functional dr be best to have homocysteine levels checked? Thank you for any help !
Anyone can check your homocysteine levels even nurse practitioners, Functional medicine doctors I have found seem to be more familiar with this mutation. Geneticist would also be familiar with these mutations they can cause a lot of havoc in the system. You would also want your Bs and folate tested.
Do you have PD?
Short answer no, my mother in law does she lives with us. I have neuropathy, MCAD, EOE, EDS and POTS but I see so much over lap in my research.
For me, I've been looking into iron for the last couple of years. Anemia in the blood is a sign of excess iron in tissues, ie where you don't want it. Problem with unbound iron is that it's oxidative and inflammatory and, as I understand it my physics is poor, steals electrons from previously stable dopamine cells because it's now in the brain. Hence why pharmas are now trialling drugs like deferoprone to chelate it out.
My dad has the Mrthfr gene so, as you've said, poor vitamin absorbtion and high homocysteine, low methylation ie getting rid of the crap he's exposed himself to all these years like roundup and diesel.
It's funny because I see three people in my family, all with separate issues - RLS, Parkinsons, 'anemia' - and they all have three things in common; iron.
I also wonder if this is iron related.i had very low iron and 2 iron transfusions and my symptoms date back to around then. Difficult to be sure though.
Check homocysteine levels if high easy fix with trimethylglycine. Little to no side effects. Research it and talk to your doctor about it
Hi. I'm interested in your (and your mother-in-law's) protocol and dosage for taking trimethylglycine to control homocysteine levels.
Do you know if it had any interactions with her Parkinson's drugs?
No interactions but everyone is different the best thing you can do is a full vitamin level check. We use Dr. Axe's HomocysteX Plus which has methlylated Bs and trimethylglycine. However it's important to know all your vitamin levels even if you have to outsource to a lab on your own. Dr.Debra Gorman is a friend of mine who can give good resources for labs to check my vitamins. If you just message her she is very good with helping others. linkedin.com/in/dr-debra-go... . Once the processes start working again with the supplements you will have to back off. You can get overmethlyated and it will cause anxiety. Another thing that comes to mind with these is despression /anexity is often low vitamin D in which you also need K to help the absorbtion.. These vitamins all work together so it really is like an orchestra. The Mental / Anger that sometimes sets in at the end of PD in my theory is the low B3 Niacin which has lots of studies that show when low/depleted contribute to mental illness. Just a fact I thought I would share.
Wow. Thank you! 
Yes I feel the same way when I look at my kids I see RLS, anemia and my oldest daughter was having trouble conceiving because of MTHFR and high homocysteine levels and she was also having iron storage problems in her 20s feeling fatigued. So I can totally relate. I started food grade diatomaceous earth and activated charcoal to see if they would help with toxins. From what I know they act as binding agents but I know nothing about expelling toxins from brain barrier for neurological symptoms.
I think a lot of these chronic issues and degenerative issues are somewhat related. It seems likely the "corrosive" build up just happens in different pathways so has different end site ie brain , organ, connective tissue and for some with even more than one diagnosis has a higher build up of "corrosive" factor ie..iron, homocysteine could be the root. Seems plausible … Back to Proper Vitamins and Nutrients the doctors didn't tell us though that 40% of the population has trouble absorbing vitamins and expelling toxins and we need a little help.
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