Sorry about your sprained ankle, if you are off running for more than two weeks it would be best to go back a few weeks, less than two weeks just continue where you left off.
As stated in the guide to the plan, healthunlocked.com/couchto5... you lose no significant condition in the first two weeks of non running.
After that loss of condition is gradual.
All any of us can do after a lay off is to go out and see what we can comfortably manage, then build back up gently, using C25k or something similar as a guide to weekly increase.
You're not alone. I was in my final run, my w9/r3 of the C25k programme when my hip muscle (TFL) twanged! Gutted, I managed to limp home. So I'm taking some time out and monitoring how the muscle feels by walking, then some short runs, and hoping to get back to running over the summer, and finally get my 5k done. Just another challenge along the journey.
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