CBD oil

[GrasszHoping]

Are their any studies about CBS oil lowering wbc counts. If so, where do those white blood cells go? To the lymph nodes? or Does the body get rid of them?

[AussieNeil Partner Administrator]

I haven't come across an update to this cautionary advice from a presentation at ASH2019; "Our findings suggest that the drug might promote homing of lymphoma cells from blood into secondary lymphoid organs where they receive pro-survival signals. Therefore, this cannabinoid compound should be used with caution in patients with indolent leukemic lymphomas. Further studies are needed to dissect the signaling pathways affected by cannabinoids in B-cell lymphoma."

healthunlocked.com/cllsuppo... So that research could explain why CBD oil might lower the blood lymphocyte count and hence WBC, but by doing so, could accelerate CLL. This is why it's important to monitor the total CLL tumour load - how the spleen and nodes change in size and how other blood counts change due to changes in bone marrow infiltration when assessing the effectiveness of any intervention

Of interest, in today's catch-up of possibly CLL related news, I came across a special series by NPR on how the lack of federal US legislation for cannabis products is putting people who use such products at risk. From Even where weed is legal, product safety isn't guaranteed

npr.org/2025/02/04/g-s1-463...

"Outside experts are deeply concerned about marijuana product safety, even in the regulated market. They don't totally blame state regulators, since there is little to no research on health impacts of different contaminants in cannabis. It's not definitely known if any state's testing system is looking for the right things at the right levels.

"It's hard to make judgments on if it's right or wrong when there's like zero data to really go into the health impacts," said Tess Eidem, a senior research scientist at the University of Colorado, Boulder's lab for aerobiology and disinfection.

She said there's some research on molds like Aspergillus, which can in rare cases lead to serious medical issues, especially for immunocompromised marijuana users. But there's no data on how smoking versus vaping, for instance, affects the amount of contaminants that ends up in the lungs." (My emphasis)

That article referenced the following concerning studies on PubMed.

Cannabis Use and Fungal Infections in a Commercially Insured Population, United States, 2016

pmc.ncbi.nlm.nih.gov/articl...

Among patients with fungal infections, persons who used cannabis were significantly younger than persons who did not use cannabis (median age 41.5 years vs. 56.0 years; p<0.001), more likely to be immunocompromised (43% vs. 21%; p<0.001), more likely to be hospitalized on the fungal infection diagnosis date (40% vs. 13%; p<0.001), and more likely to have tobacco use codes (40% vs. 9%; p<0.001) (Table).

Untested, Unsafe? Cannabis Users Show Higher Lead and Cadmium Levels

pmc.ncbi.nlm.nih.gov/articl...

Neil

[GrasszHoping in reply to AussieNeil]

Thank you for your response, AussieNeil. I know if you have 17p53, your body would not be able to get rid of dead b cells via kidneyd without one of the new drugs to help. Is it obinutusimab,gayzeva???

[AussieNeil Partner Administrator in reply to GrasszHoping]

Obinutuzumab (Gazyva) along with rituximab and other anti-CD20 monoclonal antibodies are classified as immunotherapy treatments. While they are somewhat effective against 17p del and mutated TP53 CLL in that they target CLL cells for destruction by our immune system via antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity, they still rely on an intact 17p chromosome with functional TP53 to kill CLL cells in a third manner, by activating intracellular death signaling pathways (apoptosis). The newer targeted therapies, BTK and BCL-2 inhibitors (the 'brutinibs' and 'toclax' drugs respectively, work much better when we have 17p del or mutated TP53 CLL.

Speaking of targets, you might find this paper of interest; Cannabinoid Receptors Are Overexpressed in CLL but of Limited Potential for Therapeutic Exploitation, from PLOS1, June 2016: journals.plos.org/plosone/a...

Neil

[GrasszHoping in reply to AussieNeil]

Thank you for your response, Neil. Especially the reference to the paper. My primary md recommended the CLL. I had my doubts so that's why I brought up on this very informative forum. Joyce

[Baz209]

It would increase the WBC, I've tried it. In my opinion, it would depend on what type of leukemia (as some types lower the WBC), whether that'll help. It's like any medication. One thing isn't a bullet for all.

[Pinecrest]

Along with AussieNeils warning, be careful with CBD if you are taking medication that warns you not to eat grapefruit because CBD is similar to grapefruit in that it also binds with liver enzymes. Research suggests that it’s possibly even more potent because it binds in multiple parts of the gut and liver (grapefruit mainly affects enzymes within the small intestine) and can cause the medication to enter your bloodstream at higher levels. Google CBD and grapefruit if you want to read more.

[LG1948]

I believe that the CLL Society CLL Society recommends Vitamin D3

[AussieNeil Partner Administrator in reply to LG1948]

Having your vitamin D checked to see if supplementation is needed has been in our living well with CLL tips for around a decade or so healthunlocked.com/cllsuppo...

9) ASK FOR BLOOD TESTS for Vitamin B and Vitamin D. Low levels of these are surprisingly common and can usually be rectified with supplements. Boosting them into normal levels can help with fatigue and depression, though some people cannot absorb Vitamin B12 orally and it needs to be given via injections.

Recent research has confirmed that having your serum vitamin D in the normal range correlates with a longer life expectancy with CLL.

Neil

[LG1948 in reply to AussieNeil]

Thank you

[LG1948 in reply to AussieNeil]

What is the research on cannabis and CLL?

[AussieNeil Partner Administrator in reply to LG1948]

Did you read my earlier replies above? healthunlocked.com/cllsuppo...

healthunlocked.com/cllsuppo...

[LG1948 in reply to AussieNeil]

Yes I did. Thank you for the information. Working on quitting weed but it’s a work in progress. It isn’t good for me generally and I guess having CLL makes it not good at all. Part of the problem is the much higher levels of THC that’s in legal cannabis. It’s very easy to get dependent on it.