I thought it might be helpful to share the antibody results of my Evusheld injections. I was first diagnosed with CLL in 2013 and started Ibrutinib in February 2020. I received my first Evusheld injections on February 1, 2022 and 2nd injections on March 3, 2022. Covid antibody tests were done in September 2021, Dec 2021, March 2022 and June 2022. Note that prior to the Evusheld treatments in Feb and Mar 2022 I had no antibodies....
Thanks for sharing. Don’t really understand what all these individual results ultimately mean. Wondering where you had your test done? I’m somewhat similar too you. On ibrutinib during all vaccines and Evusheld, recently changed to zanubrutinib. After 3 Pfizer and 1 Moderna zero antibodies. Seven weeks after full dose Evusheld, per Lab Corp Spike Quant result 1192 antibodies. Would of liked to have seen something like 10,000 antibodies. But as a very smart philosopher once said, “it is what it is”.
I’m on Alliance clinical trial at UT Southwestern in Dallas. The tests were done at the lab at UT southwestern and ordered by clinical trial doc. I’m with you on understanding the numbers….not sure anyone really does… I’m assuming positive is certainly better than negative!
I'm very curious about these Evusheld results too. Thanks for sharing. We're jealous! lol
My husband was on Ultra V until late April. Previously had 3 Moderna shots - nothing. Then in early May finally figured out where to get Evusheld. Yay!
BUT 3 weeks after the Evusheld shot - NOTHING. His antibody test came back with negative result. What happened?
Anybody who understands this science better than me want to comment? (That is not a high wall to scale. ha We're statisticians so I'm good with data but honestly my science reading brain space was all used up getting husband to the trial/navigating trial information/covid/and lately reading about the UltraV/umbralisib crash - a whole other thing!)
I had 2 Pfizer vaccines and 1 booster. I asked Doc if getting a 2nd booster was a waste of time since the first 3 didn’t produce antibodies. He responded that he didn’t believe there was any benefit to a 2nd booster for me but not a lot of risk either.
I have had two Pfizer vaccines and two boosters of the same. I am due for another booster in early July.
My son recently tested positive for Covid five days ago. We had spent time with him the prior two days. He had no symptoms then.
But I was concerned I would get Covid. However, I seem to have escaped this fate.
My son has been vaccinated and boosted. He likely was exposed at the gym, which he had recently started going back to. He always wore a mask but not everyone did.
Because he was vaccinated and boosted, we are hypothesizing that he did not expel a high viral load. Not even his wife caught Covid.
I have been trying to get my various doctors to prescribe Evusheld but have had no luck in this regard. Perhaps prior to starting treatment this might occur. That decision will come up again in mid July.
Glad that you dodged Covid! Have you gotten a Covid antibodies test? If you get the test and test negative for antibodies that might help persuade docs to prescribe Evusheld.
I could be wrong but I don’t think they give Evusheld if you have antibodies. I’m in the U.S. and took part in a study through the Leukemia, Lymphoma Society to see how we did with the covid vaccines and if you got antibodies then you wouldn’t get Evusheld.
From the FDA Emergency Use Authorization, here are the Evusheld eligibility requirements for adults and children (12 years and older weighing at least 40 kg)Who are not currently infected with SARS-CoV-2 and who have not had a known recent exposure to an individual infected with SARS- CoV-2 and
• Who have moderate to severe immune compromise due to a medical condition or receipt of immunosuppressive medications or treatments and may not mount an adequate immune response to COVID-19 vaccination or
• ForwhomvaccinationwithanyavailableCOVID-19vaccine, according to the approved or authorized schedule, is not recommended due to a history of severe adverse reaction to a COVID-19 vaccine(s) and/or COVID-19 vaccine component(s).
I recently had the Evusheld duo of shots. After that I tried to find out how soon I could be tested and which type of test I should have. What I found out is that no testing is necessary after Evusheld. These injections “flood” you with antibodies, you don’t need to develop them yourself as with the vaccines.The other thing to note is that Evusheld’s protection lasts 6 months, so there is no need to have the next one sooner.
Evusheld does onboard antibodies. But it isn’t 100% effective (even in the PROVENT trial (pre-omicron) it was in the 77-83% range.)
In February, 2022, the FDA came out recommending doubling the evusheld dosage, publishing a memo outlining decision to double evusheld dosing, that their revised dosing "may provide 3 months duration of protection against the Omicron subvariant BA.1 and 1 to 3 months protection against BA.1.1." [Which is 2x dose for 1/2 the length of original time period given.]
Pg 4 - “Pharmacokinetic (PK) Modeling to Predict an Adequate Dose for PrEP
Our PK modeling assessment of the available data to date predict that the currently authorized 300 mg (150 mg of tixagevimab and 150 mg of cilgavimab) single and repeat (every 6 months) EVUSHELD IM dosing regimens are suboptimal considering the significant reduction in AZD7442 activity in cell culture against the SARS-CoV-2 Omicron subvariants BA.1 and BA.1.1 discussed above. Based on our modeling parameters, a single EVUSHELD 600 mg IM (300 mg of tixagevimab and 300 mg of cilgavimab) dose may provide 3 months duration of protection against the Omicron subvariant BA.1 and 1 to 3 months protection against BA.1.1. Therefore, the EVUSHELD IM dose will be increased to 600 mg (300 mg tixagevimab and 300 mg cilgavimab) for PrEP to increase the likelihood of attainment of a minimum protective concentration based on in vitro neutralization activities of EVUSHELD against the Omicron subvariants (see below). Note because of the uncertainty in forecasting future circulating subvariants in general as well as which ones will be major subvariants the repeat dosing regimen will be removed at this time and updated later when more data are available”
Hello, thanks for sharing. I was diagnosed with CLL last May. I had an Evasheld vaccine this past February. What is the significance off the negative vs. positive readings and how do they apply to your CLL?
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Evusheld reaction
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