As many of you know, I enrolled in a clinical trial for experimental treatment with the goal to reduce MRD to zero.
(Minimal (or Measurable) residual disease
Description:Minimal residual disease is the name given to small numbers of leukaemic cells that remain in the person during treatment, or after treatment when the patient is in remission. It is the major cause of relapse in cancer and leukemia.)
I began the trial last July. After three months, my MRD had reduced by 75%, a result which was described by my care team as exceptional. This morning, I received the results of my six month labs and my MRD are down 99% and it looks like I am heading towards MRD Negative (in lay language remission.)
MRD:
Pre trial – July 2020 16.80%
At cycle 3 – October 2020 4.26% 75% DECREASE
At cycle 6 – December 2020 0.13% 99% DECREASE
I anticipate that my next result at month nine will be MRD Negative
Happy new year!
ClinicalTrials.gov Identifier: NCT04016805
Recruitment Status : Recruiting
First Posted : July 11, 2019
Last Update Posted : December 2, 2020
Study to Assess the Efficacy and Safety of Ublituximab and Umbralisib in Subjects With Chronic Lymphocytic Leukemia (CLL) Currently Treated With Ibrutinib, Acalabrutinib or Venetoclax
“MRD: What Should It Mean to Me?” Ever dreamed of coming to a point where your CLL treatment could be safely stopped? View CLL Webinar.
MRD negative
Well the results are in. 
