Good end to a bad year... My MRD Results are in!

[MikeHoff]

As many of you know, I enrolled in a clinical trial for experimental treatment with the goal to reduce MRD to zero.

(Minimal (or Measurable) residual disease

Description:Minimal residual disease is the name given to small numbers of leukaemic cells that remain in the person during treatment, or after treatment when the patient is in remission. It is the major cause of relapse in cancer and leukemia.)

I began the trial last July. After three months, my MRD had reduced by 75%, a result which was described by my care team as exceptional. This morning, I received the results of my six month labs and my MRD are down 99% and it looks like I am heading towards MRD Negative (in lay language remission.)

MRD:

Pre trial – July 2020 16.80%

At cycle 3 – October 2020 4.26% 75% DECREASE

At cycle 6 – December 2020 0.13% 99% DECREASE

I anticipate that my next result at month nine will be MRD Negative

Happy new year!

ClinicalTrials.gov Identifier: NCT04016805

Recruitment Status : Recruiting

First Posted : July 11, 2019

Last Update Posted : December 2, 2020

Study to Assess the Efficacy and Safety of Ublituximab and Umbralisib in Subjects With Chronic Lymphocytic Leukemia (CLL) Currently Treated With Ibrutinib, Acalabrutinib or Venetoclax

[Mystic75]

Great results, Mike! I am so happy for you - all the best for 2021!! 🥂

[Phil4-13]

YES!!!!!! Fabulous News! Sandra

[Ghounds]

Amazing! So pleased for you.

[Sushibruno]

CONGRATS Mike, what was the name of the trial u were enrolled in?

[Jm954 Administrator in reply to Sushibruno]

It's in his post

[Sepsur]

Great news - what a way to see in the Ny

[Hidden]

Good news! Keep it up! All the way!

[Jackpot]

I am so happy for you. Excellent news!

[CLLCalifornia-USA]

Congratulations. Great way to leave 2020 behind and start 2021 with nothing but positives. Happy New Year. Sally

[DisneyMom]

Congrats! Great news!

[very]

Great news and a great start to 2021.jenny uk

[Eucalyptus22]

An excellent way to start the new year.

[Jm954 Administrator]

Good news and really please for you with your results. Which treatment were you receiving before the trial treatments?Jackie

[MikeHoff in reply to Jm954]

Ibrutinib 420 mg for 2 years then reduced to 280 mg for 2 years

[Solentgirl]

Brilliant News!!!! Happy New Year ! Teresa

[Floxxy]

Fab news. X

[MikeHoff]

For those who asked in case you missed it...

I am on Phase 2 Trial...

ClinicalTrials.gov Identifier: NCT04016805

Study to Assess the Efficacy and Safety of Ublituximab and Umbralisib in Subjects With Chronic Lymphocytic Leukemia (CLL) Currently Treated With Ibrutinib, Acalabrutinib or Venetoclax

I believe they are still recruiting . Go to clinicaltrials.gov and search the above identifier.

I was diagnosed ten years ago. Six years W&W. One unsuccessful treatment of Bendamustine and rituxine. The Ibrutinib for four years.

[Hidden]

Wow! Excellent results. Really happy for you and the potential future for all of us. Thanks for participating in the trial.

[CCgroup]

Well done!! I'm on ibrutinib and will follow your progress with interest - a definite Happy New Year.For those who asked why my doctor recommended I stop flu shots early last year, it was because they felt my low immune level could cause the jab to give me the flu it was supposed to protect me from. It is why I'm following the results of those taking the virus shots.

Went for a covid test yesterday - good news. So far so good.

Happy New Year!!

[Iupiter]

Great news! What arm were you on? Do you know?

[MikeHoff in reply to Iupiter]

Ublituximab and Umbralisib With Ibrutinib

[LAbayway]

This is wonderful news to end the year with. Awesome.👍👍👍