Venetoclax plus obinutuzumab - the first chemotherapy-free, fixed-duration first line CLL treatment approved by Health Canada

[AussieNeil]

* VENCLEXTA® (venetoclax) plus obinutuzumab is the first chemotherapy-free,

fixed-duration combination regimen approved by Health Canada for patients

with previously untreated chronic lymphocytic leukemia (CLL).

* Approval is based on data from the Phase 3 CLL14 trial, which showed that

patients treated with obinutuzumab plus one year of treatment with

VENCLEXTA had clinically meaningful and statistically significant

progression-free survival (PFS) and higher rates of undetectable minimal

residual disease compared to patients receiving a standard of care

chemoimmunotherapy regimen of obinutuzumab and chlorambucil

bloomberg.com/press-release...

This is an unlocked post: healthunlocked.com/cllsuppo...

Neil

[seelel]

If it's good for Canada, then here's hoping it will soon become good for Australia.

[Canuck901]

Excellent news! Thanks. Wonder which provinces have also approved this treatment

[AussieNeil Administrator in reply to Canuck901]

It was my understanding that Health Canada manages the approval process for all of Canada, but the treatment funding is the responsibility of the respective provinces and territories. Is that correct?

[Canuck901 in reply to AussieNeil]

Yes that’s the just of if , so this should be available in 3-4 months . I also wonder if this would be available on compassionate basis by the AbbieVie.

Something for Canadians to discss with their CLL specialist.

I believe that this is the latest and probably most effective treatment for CLL at the moment.

I guess the only question is 12 months long enough ?

[studebaker]

Thank you Neil. This is excellent news. Unfortunately for me, I don’t qualify for the group of before untreated patients.

I am going to have discussion with my doctor about the possibility of adding Venetoclax after some time being on Acalabrutinib. Just the idea of being able to get longer time with no treatment is very appealing to me.

You must be getting there soon Neil. Good luck to you.

🤗

Dana

[Canuck901 in reply to studebaker]

Yeah obinituzimab and Venetoclax looks like it’s just for first line treatment while the Rituximab and Venetoclax is for relapse

[studebaker in reply to Canuck901]

Good thing is there are possibilities for us. Since I already had Obinutuzumab as my first treatment, I have to discuss this with my doctor when the time comes if I would only have to take Venetoclax.

Where is our Spring ?

Dana

[Canuck901 in reply to studebaker]

When did you get obinituzimab? Before your acalabrutnib?

[studebaker in reply to Canuck901]

Yes, my first treatment was Obinutuzumab and Chlorambucil. Acalabrutinib is my second run.

[Canuck901 in reply to studebaker]

Since these combo therapies seem to become more prevalent now with Venetoclax. Woujd be a good Time to ask if Venetoclax can be added to acalabrutnib