ibrutinib and palpitations

[Bixilon]

Hi. I have been treated with Ibrutinib, 2 years and 5 months ago, it has been going well for me. but I have palpitations and before starting ibrutinib I had a mild heart attack. These palpitations began to treat me with amiodorone, in small doses, but it brings ugly consequences for my thyroid. I am in a dilemma if palpitations are reduced under the dose of ibrutinib, but my nodes swell, if I continue with amiodorone, the thyroid is complicated, the liver is complicated. I live in Argentina . Has it happened to anyone? How do they cope? Thanks

[PlanetaryKim]

Hi Bixilon. I have heard some people report that if their doctor switches them to acalabrutinib instead of ibrutinib, the heart problems go away. Is that an option for you? Perhaps you could discuss with your doctor. Acalabrutinib is the next-generation version of ibrutinib and reportedly has less "off target" effects.

kim

[Bixilon in reply to PlanetaryKim]

thank you for answering. I will find out if it is available in my country. Hopefully it doesn't have those side effects than ibrutinib.

[Hidden]

I believe the other option is a smaller dose. Heart issues are one of the side effects of this drug.

[Bixilon in reply to Hidden]

If you try to reduce the dose and take 280mg. but the gañglio return and the numbers of lymphocytes increase.😢

[Bixilon in reply to Bixilon]

Try reducing the dose and take 280 mg. but the nodes return and the numbers of lymphocytes increase.

[Hidden in reply to Bixilon]

Sorry to hear that. I already have afib and racing heart and I am on verapamil for BP which heightens the effects of imbruvica. This is day 3 for me - so far so good but I think it the cumulative effect of the drug is when some of the riskier side effects kick in. I am concerned about this myself. Best wishes for your search.

This link is for an excellent booklet by the Leukemia and Lymphoma society in the states. (lls.org) it gives the various treatment options for cll. you can also email or live chat with them online as well.

lls.org/sites/default/files...

[Bixilon in reply to Hidden]

thank you for your concern. It seems that acalabrutinib is available in my country, and it is a more friendly drug. I wish you luck