ibrutinib and palpitations: Hi. I have been... - CLL Support

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ibrutinib and palpitations

Bixilon
Bixilon

Hi. I have been treated with Ibrutinib, 2 years and 5 months ago, it has been going well for me. but I have palpitations and before starting ibrutinib I had a mild heart attack. These palpitations began to treat me with amiodorone, in small doses, but it brings ugly consequences for my thyroid. I am in a dilemma if palpitations are reduced under the dose of ibrutinib, but my nodes swell, if I continue with amiodorone, the thyroid is complicated, the liver is complicated. I live in Argentina . Has it happened to anyone? How do they cope? Thanks

7 Replies
oldestnewest

Hi Bixilon. I have heard some people report that if their doctor switches them to acalabrutinib instead of ibrutinib, the heart problems go away. Is that an option for you? Perhaps you could discuss with your doctor. Acalabrutinib is the next-generation version of ibrutinib and reportedly has less "off target" effects.

kim

thank you for answering. I will find out if it is available in my country. Hopefully it doesn't have those side effects than ibrutinib.

Hidden
Hidden

I believe the other option is a smaller dose. Heart issues are one of the side effects of this drug.

Bixilon
Bixilon
in reply to Hidden

If you try to reduce the dose and take 280mg. but the gañglio return and the numbers of lymphocytes increase.😢

Bixilon
Bixilon
in reply to Bixilon

Try reducing the dose and take 280 mg. but the nodes return and the numbers of lymphocytes increase.

Hidden
Hidden
in reply to Bixilon

Sorry to hear that. I already have afib and racing heart and I am on verapamil for BP which heightens the effects of imbruvica. This is day 3 for me - so far so good but I think it the cumulative effect of the drug is when some of the riskier side effects kick in. I am concerned about this myself. Best wishes for your search.

This link is for an excellent booklet by the Leukemia and Lymphoma society in the states. (lls.org) it gives the various treatment options for cll. you can also email or live chat with them online as well.

lls.org/sites/default/files...

Bixilon
Bixilon
in reply to Hidden

thank you for your concern. It seems that acalabrutinib is available in my country, and it is a more friendly drug. I wish you luck

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