My husband has been on ibrutinib for 7 months & it has been working well for him with minor side effects (small rash, some joint pain) until the last month. His white blood count is coming down very slowly - still at about 60. (He is waiting to get a stem cell transplant in January & has had FCR but relapsed). In the last month though he struggled with a cold and terrible cough which got better after antibiotics, but has been very irritable and his feet bother him every night - going from being icy cold to stinging and hot. We suspect neuropathy and his hematologist has told him to stop taking ibrutinib for a few days. Immediately after stopping, he has been cheerful and his feet have not bothered him as much. This is great, but really worries me as to what they will do with him next. Has anyone else had experience with ibrutinib and neuropathy?