CLL Support Association
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FCR on Flair trial at Christie Hospital

71yr male diagnosed 2yrs ago, CLL (Binet stage B) researched specialists and decided on Dr Bloor at Christie Hospital in Manchester, an excellent choice. W&W for 18 months until he found a mass of raised lymph nodes in my abdomen. Dr Bloor suggested the Flair trial and I was randomised for FCR beginning mid Oct.

My HDMS sample showed a typical CLL phenotype with germline IgVH and trisomy 12

I believe this means my likely remission after the FCR is reduced to approx 2/3 yrs.

Have now had three monthly treatments, the next is due 10/1/18. Side effects so far have been minimal, felt rough on days 4/5 after the first dose, less so after the second dose and ok after dose three. I had a change of anti sickness tablets last time to ondanestron, which I took twice a day for the 5 day treatment period, Hopefully this is the reason I felt okay. Previously I had a single Akynzeo tablet before starting the Rituximab infusion and a supply of Metoclopramide to take if needed.

I had a rash on my body after the first round, the Co- Trimoxazole anti-biotic tablets were replaced by Pentamidine 300 mg via nebuliser for rounds 2&3. I also take 800 mg of Aciclovir every day

Will update this post after my next treatment

4 Replies
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Hi Anthony, welcome to our community.

You made an excellent choice of hospital/ consultant, I’ve been supported by the same team since diagnosis in 2012 when I too was treated with FCR.

I relapsed at the end of 2016 and am now on a clinical trial again supported by the same team.

Best rob

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Thank you Rob, we are fortunate to have this team at The Christie, I have complete confidence in them all. Good luck with your new treatment.

Kind Regards,

Tony

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Hi Anthony and welcome to the group. You seem to have an excellent support team, a good knowledge of CLL and your condition, all of which plays heavily in your favour. I hope your remission is strong and that you can enjoy a healthy 2018. Please keep in touch about how you are getting on.

Brian

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Hi Brian,

Thanks for your message, I feel lucky so far that the effects of the FCR have been limited to a couple of days feeling grim, no sickness or other probs. I am due my fourth treatment next Weds 10/01, hopefully the same response will apply.

I have a suspicion that the ondenestron anti- emetic tablets were responsible for me feeling fine after No 3.

Kind Regards,

Tony

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