FCR on Flair trial at Christie Hospital

[Anthonymac]

71yr male diagnosed 2yrs ago, CLL (Binet stage B) researched specialists and decided on Dr Bloor at Christie Hospital in Manchester, an excellent choice. W&W for 18 months until he found a mass of raised lymph nodes in my abdomen. Dr Bloor suggested the Flair trial and I was randomised for FCR beginning mid Oct.

My HDMS sample showed a typical CLL phenotype with germline IgVH and trisomy 12

I believe this means my likely remission after the FCR is reduced to approx 2/3 yrs.

Have now had three monthly treatments, the next is due 10/1/18. Side effects so far have been minimal, felt rough on days 4/5 after the first dose, less so after the second dose and ok after dose three. I had a change of anti sickness tablets last time to ondanestron, which I took twice a day for the 5 day treatment period, Hopefully this is the reason I felt okay. Previously I had a single Akynzeo tablet before starting the Rituximab infusion and a supply of Metoclopramide to take if needed.

I had a rash on my body after the first round, the Co- Trimoxazole anti-biotic tablets were replaced by Pentamidine 300 mg via nebuliser for rounds 2&3. I also take 800 mg of Aciclovir every day

Will update this post after my next treatment

[Oleboyredw-uk]

Hi Anthony, welcome to our community.

You made an excellent choice of hospital/ consultant, I’ve been supported by the same team since diagnosis in 2012 when I too was treated with FCR.

I relapsed at the end of 2016 and am now on a clinical trial again supported by the same team.

Best rob

[Anthonymac in reply to Oleboyredw-uk]

Thank you Rob, we are fortunate to have this team at The Christie, I have complete confidence in them all. Good luck with your new treatment.

Kind Regards,

Tony

[pkguk2 Partner CLL Support Association]

Hi Anthony and welcome to the group. You seem to have an excellent support team, a good knowledge of CLL and your condition, all of which plays heavily in your favour. I hope your remission is strong and that you can enjoy a healthy 2018. Please keep in touch about how you are getting on.

Brian

[Anthonymac in reply to pkguk2]

Hi Brian,

Thanks for your message, I feel lucky so far that the effects of the FCR have been limited to a couple of days feeling grim, no sickness or other probs. I am due my fourth treatment next Weds 10/01, hopefully the same response will apply.

I have a suspicion that the ondenestron anti- emetic tablets were responsible for me feeling fine after No 3.

Kind Regards,

Tony