Shortly after my 5th treatment I became sick. Despite 4 rounds of antibiotics I could not shake it and my last treatment was delayed until I was well. Unfortunately I ended up in the hospital with pneumonia where I am now. It has now been 7 weeks since my last treatment. My recent PET/CT scan shows all nodes and spleen have reduced and there is no sign of disease.
Here is my question. If there is no sign left is there a benefit to having the last treatment? By doing so will I keep CLL at bay longer. Or am I at greater risk of getting sick from the last chemo treatment and risking more serious infection. I have tried finding scientific research to show 6 treatments makes a difference but am coming up short.
Can someone direct me data or share your experience?
I am 44 with a daughter who just finished her freshmen year of college and I want to keep this a bat as long as possible. FYI I am 11q, unmuted, ATM
Thanks!
Written by
Mnance
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Thanks for your answer to my earlier post.Concentrate on getting better and then listen to what your specialist advises. Many have remissions after only 4 treatments of FCR.
The best test on depth of remission is an MRD flow cytometry on the blood. This will tell the number of malignant cells remaining. The best remission is called MRD negative, and is 1 CLL cell in 10,000 leukocytes...
The blood MRD is not as good as the bone marrow varient, but they can't do the BMB test until atleast 3 months after the last infusion of rituxan... because it is still on the job...
There are papers on dose reductions of FCR, but no studies I have seen on the long term effects of reduced treatment rounds...
I had 4 rounds of FCR when I was 41 yrs. I had a delay before the 5th round due to sickness and in the meantime a MRD test was done on the blood (not sure why). It came back negative and further cycles were held off until 3 months later when I had a BMT which also came back MRD negative, so I had no further FCR. My last cycle was March 2010. I am classed as in partial remission because of node in my torso not reducing by (or to) a specific size. Things are still looking positive as my wbc and lymphocytes are still well within the normal range. My only concern is that over the last 18 months or so my platelets dropped gradually to 96 and if it had dropped any more further investigation (BMT) would be required. Platelets increased on my last visit to 112, so hopefully things are on their way to normal. Only other issue is the number of colds and minor infections but that seems to go with the territory with cll.
Hope it all works out. I just took the advice of the Drs.
Personally I'd ask "What is the expected benefit of this last round,please?"
If its not obvious then I'd suggest that you hold off.
I did 5 rounds, was told I was slightly anaemic but should continue. After round 6 I was given an appointment to return in 3 months. In the interim I was so anaemic that I collapsed and spent 16 days of my foreign holiday in hospital, and received at least 10 pints of blood. Two years later and I am still on monthly IVIG treatment, as well as PCP preventive treatments as I catch lung germs very easily now.
I had 4 then couldnt take anymore! There is no reason to carry on if the results are good. Also a lot of new cancer treatments will soon be available that are less toxic.
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