Update on Novel B-Cell Receptor Signaling Inhibitors from NCCN 8th Annual Congress on Hematologic Malignancies

Update on Novel B-Cell Receptor Signaling Inhibitors from NCCN 8th Annual Congress on Hematologic Malignancies

The article below from OncLive, provides a high level overview of trials experience of the new drugs Ibrutinib, Idelalisib and IPI-145 by Jeffrey Jones, MD, from The Ohio State University to the NCCN 8th Annual Congress on Hematologic Malignancies. Brief mention is also made of the benefits observed when using Ibrutinib with Ofatumumab (Arzerra) and rituximab.

Drugs targeting B-cell receptor (BCR) signaling pathways are improving outcomes for patients with B-cell lymphomas, including chronic lymphocytic leukemia (CLL), non-Hodgkin lymphoma (NHL), and mantle cell lymphoma (MCL). These novel agents include PI3-Kinase (PI3K) inhibitors (eg, idelalisib) and Bruton’s tyrosine kinase (BTK) inhibitors (eg, ibrutinib), and are considered a breakthrough for CLL and other B-cell lymphomas.

At the recent NCCN 8th Annual Congress on Hematologic Malignancies, Jeffrey Jones, MD, from The Ohio State University Comprehensive Cancer Center and James Cancer Hospital and Solove Research Institute, updated listeners on these two new targeted drug classes:

onclive.com/publications/ob...

Neil

(This Musk Lorikeet proved challenging to photograph, as it was very actively foraging for nectar and pollen from the bottlebrush shrub.)

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  • Neil, it seems to be the conference time of the year - yet another positive article about these inhibitors

    Although is it compulsory to swallow a dictionary before standing on stage!

    Definition of concomitant in English --- naturally accompanying or associated:

    she loved travel, with all its concomitant worries

    Great photo - most UK birds are black, grey or brown - I suppose our birds needed to hide from hunters whereas your birds can see and hear a boomerang coming!!!!

    Marty

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