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Good news from The Royal Marsden

From their press release:-

A new model for genetic testing in cancer patients. 21 May 2013

A research programme that will lay the foundations for anyone with cancer to have access to genetic testing has been launched with £2.7 million funding from the Wellcome Trust.

Led by a team at The Institute of Cancer Research, London, in collaboration with The Royal Marsden and the Wellcome Trust Centre for Human Genetics and Illumina, the programme will implement a new patient pathway for cancer gene testing so that more genes can be tested in more people.

Gene mutations

Mutations in some genes, known as cancer predisposition genes, greatly increase the likelihood that a person will get cancer. There are nearly 100 known cancer predisposition genes, but testing for them in the UK is currently very restricted.

Recent advances in methods for reading the genetic code, known as sequencing, mean that looking for gene mutations is now faster and more affordable than ever before. There is now an opportunity to transform cancer gene testing and to improve the health outcomes of many people with cancer and their families.

Professor Nazneen Rahman, lead investigator of the programme and Head of Genetics at the Institute of Cancer Research (ICR) and theCancer Genetics Unit at The Royal Marsden, explains: “It is very important to know if a mutation in a person’s genetic blueprint has caused their cancer. It allows more personalised treatment, so for example such people are often at risk of getting another cancer and may choose to have more comprehensive surgery, or may need different medicines, or extra monitoring.

The Mainstreaming Cancer Genetics programme aims to develop the laboratory, analytical, interpretative and NHS clinical capabilities required to make cancer predisposition gene testing information routinely available in the clinic.

Data analysis

Generating the gene information is only the first-step. The data needs to be correctly analysed in order to identify any mutations. Then the effects of the mutations need to be correctly interpreted so doctors can make the appropriate clinical recommendations.

“Analysing genetic data and understanding how mutations actually affect a person is hugely complex. A real strength of this programme is that the analysts are working directly with the people in the lab generating the data and the doctors that need to use it,” said Professor Peter Donnelly, Head of the Wellcome Trust Centre for Human Genetics at the University of Oxford.

The programme also proposes a new model whereby the genetic testing can be done as a routine part of cancer treatment. Currently all cancer predisposition gene testing is done by geneticists. In the new model it is proposed that testing in cancer patients will also be done by oncologists.

“Many people with cancer are keen to have a gene test as soon as possible to help doctors plan the best treatment for them. The complex decision-making that people without cancer have to consider before having a test often doesn’t apply. We need a more flexible system that makes the testing process simpler when appropriate. This will allow many more people to benefit from gene testing,” said Professor Rahman. The new model is being piloted, in the first instance, in women with breast or ovarian cancer at The Royal Marsden.

“Knowing whether or not a patient has a gene mutation is an important part of making personalised treatment plans. We want to be able to get the genetic information we need, when we need it. Patients are also increasingly aware of the value of genetic testing and more and more patients are requesting testing. This programme will help make genetic testing quicker and simpler and The Royal Marsden is excited to be leading on its clinical implementation,” said Professor Martin Gore, Medical Director of The Royal Marsden.

By the end of the three-year programme the team aim to have developed a ‘toolkit’ that will cover the full process involved in testing any cancer predisposition gene. This could then be used throughout the NHS, so that anyone with cancer can benefit.

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