As all with CLL know, after a FISH test we can see some of the genetic changes that have occurred due to our CLL.
With breast cancer it is changes or the inheritance of the BRCA mutations.
We tend to think of genetic changes therefore being damaging and causing cancer or a disease.
But what about changes in our genetic makeup that occur and which improve our health.?
Now we are starting to see research proving that some genetic changes, WHICH ARE COMPLETELY WITHIN OUR CONTROL, are good for us.
These first tests are for type 2 diabetes, which is an increasing problem in our over weight society.
But this initial work will doubtless be carried forwards to help us keep the good genetic changes and lower the risk of the bad genetic changes.
‘ A Six Months Exercise Intervention Influences the Genome-wide DNA Methylation Pattern in Human Adipose Tissue ‘.
‘A sedentary lifestyle, a poor diet and new technologies that reduce physical activity cause health problems worldwide, as reduced energy expenditure together with increased energy intake lead to weight gain and increased cardiometabolic health risks . Obesity is an important predictor for the development of both type 2 diabetes (T2D) and cardiovascular diseases, which suggests a central role for adipose tissue in the development of these conditions ‘.
SNIP………………
‘ In conclusion, exercise induces genome-wide changes in DNA methylation in human adipose tissue, potentially affecting adipocyte metabolism ‘.
There are a few benefits that come with CLL, including closer health monitoring via regular check-ups and the ability to measure some key indicators of your health, including cardiometabolic health from your regular blood tests.
In Australia, I get two blood test reports regularly, the Compete Blood Exam, which provides critical information on how my various blood lines are going and a Blood Biochemistry report. This latter includes among the 23 standard tests, information on how my kidneys and liver are performing along with cholesterol and blood glucose levels. These latter are normally assessed after fasting, which I don't normally bother with unless it is specifically required. That way I avoid the morning rush - being well aware that people going for blood tests generally aren't there because they are in good health...
I'm sure most members of this site would have similar regular blood testing.
My haematologist also checks my weight and blood pressure in addition to my lungs, lymph nodes, spleen and liver.
If you know you could benefit from some exercise, you can get some positive feedback by looking for improvements in some of these test results, plus the usual improvements in weight, resting pulse, fatigue levels and so on.
Even if you think that you have no time to fit in more exercise, with some thought, you can usually squeeze in what is called incidental exercise without requiring more time. Common examples are taking the stairs instead of the lift (which you can often beat during busy times), parking in the first available place at a shopping centre and using the saved time to walk instead of driving around wasting time and fuel, walking to the next bus stop if the bus is late or you are early and cycling or walking short distances from home rather than driving.
I ran as a candidate in the local elections recently. Posted leaflets through every door in the area for a week, result? 2 days in bed to get the Lymph glands to go down again.
In conclusion, exercise induces genome-wide changes in DNA methylation in human adipose tissue, potentially affecting adipocyte metabolism ‘. ...........What ?
All I know is I love riding my bike and from diagnosis to 3 and a bit years down the line my average speed has increased from 12 mph ( bit embarrasing ) to 15.5 mph ( not to Bad) so I guess it must be good for me still got along way to go to match the boys on the Tour De France. Allez Chris Froome.
Aussie Neil, Cadel evans could do well but also don't write off Alberto Contador now just need to find my performance enhancing drugs and I will be out on the Bike.
Jules
I work out 6 mornings a week but today is my day off....then I read Kwenda's blog and look at adipose,.. ok, I find out it's the correct name for the fat cells. Then I find the adipose dance on you tube.... Great I may stop shaking it about later today. Thank you Dick, its a great start to the day.
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Optical Genome Mapping: a promising new tool to assess genomic complexity - Part Two
Does CLL begin neonatal?
Why exercise alone won’t save us
Good afternoon on 75th VE Day lockdown & exercise
