Coming Off Statins - Update July 31, 2018 - Cholesterol Support

Cholesterol Support

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Coming Off Statins - Update July 31, 2018

sos007 profile image
sos007Ambassador
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For those following my progress I am updating my lipid values and the results of my NMR Lipoprofile as well as my MPO (Myeloperoxidase - arterial inflammation).

As noted in my last post, due to a lab error, my June 28th, 2018 NMR Lipoprofile and MPO value were not completed. As a result, I repeated the test on July 31, 2018.

For the record, I do not take any prescription medication. I take a baby aspirin 81 mg dosage, every other day. My INR (International Normalized Ratio) - measuring clotting time - is 1.0, which is in the normal range. I take a variety of supplements, am on a whole-foods, plant-based diet, and exercise daily.

Here are my updated values:

MPO - 223 pmol/l - same value as Oct. 2017 and well within the desirable range of <470 pmol/l;

Lipid metrics:

Total cholesterol: 5.25 mmol/l - slightly above the 5.18 mmol/l guideline but of no relevance;

HDL-C: 2.53 mmol/l - optimal value above >1.55 mmol/l;

non-HDL: 2.72 mmol/l - optimal value - below 3.37 mmol/l

LDL-C: 2.43 mmol/l - optimal value - below 2.59 mmol/l

Triglycerides: 0.59 mmol/l - optimal value - below 1.7 mmol/l

VLDL: 0.27 mmol/l - optimal value - below 0.77 mmol/l

TC/HDL ratio: 2.1:1 - optimal value below 3.5:1 guideline

Triglycerides/HDL ratio: 0.24:1 - optimal value - below 0.87:1 guideline

These are the standard measures used by the medical community - and by their current standards - my results are excellent - especially the HDL-C which is actually higher than my LDL-C and nearly as high as my NON-HDL-C value. This means due to my high HDL-C, the RCT (Reverse cholesterol transport) mechanism is clearing out all LDL-C and nearly all other atherogenic particles. Who knows, I may even be experiencing plaque regression - I won't know this until some other planned tests are done.

Now for the NMR Lipoprofile results - which I place more weight in, since this is the state of the art measure of CVD risk. It measures cholesterol lipoprotein particle numbers circulating in the bloodstream, particle size, and Insulin Sensitivity. I last completed this test in December 2017 - as can be seen from the table below, all of my values improved:

===========Dec 2017 =====July 2018 =====Guideline ========Result

LDL-P =======858 =========733 ========= <1000 nmol/l =====Optimal

HDL-P =======33 ==========38.8 ======== > 30.5 umol/l =====Optimal

Small LDL-P===162========= <90 ========== < 527 nmol/l ====Optimal

LDL size ======21.1=========21.3========= > 20.5 nm =======Optimal

Insulin Resistance Score - measures insulin sensitivity

LP-IR - ======== <25========= <25========== <45===========Optimal

This means I am 'Insulin Sensitive' or 'IS' which is the healthy state for an individual. Those who have metabolic syndrome or are type 2 diabetics are 'insulin resistant' or 'IR'.

My last LP-Pla2 test which measures plaque stability (risk of blood clots from loose plaque covering) was 79 nmol/min/mL which is slightly above (not good) the <75 optimal value. My previous score was 74 in Oct 2017. My remedy for this is to increase my fish-oil capsules to 3 doses per day from 2 doses per day. Omega-3 consumption is critical for plaque stabilization.

When assessing my overall blood metrics we can conclude that my current cardiovascular disease (CVD) risk is quite low.

I recently saw my cardiologist who performed an examination and provided an assessment of my last echocardiogram completed in October 2017. He said my Left ventrical size and Ejection Fraction of 57% indicated a heart that is operating normally. In other words, no indication of damage to the heart muscle.

-------------------------------------

My next step is to do two diagnostic tests:

1) the Carotid IMT test which uses ultrasound instead of radiation to determine the level of plaque accumulation in the body;

2) Angiodefender - which measures FMD (Flow Mediated Dilation) in the brachial artery. This will provide another view of the health of my endothelium.

Good luck to all.

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bobaxford profile image
bobaxford

Well down, seems like all is going well. Like you I am off al med except baby aspirin which I take daily. You say you still take baby aspirin every other day, perhaps I should adopt this approach. Interestingly I viewed a vide from last weeks ESC conference, I will try and post on here. One surprising view expressed was that aspirin has no benefit!

sos007 profile image
sos007Ambassador in reply to bobaxford

I know that aspirin for prevention is no longer a standard protocol except for high risk patients. I've asked my cardiologist what blood test I can take to determine the efficacy of aspirin and he said one doesn't actually exist. I did the INR test (clotting time) and it came out normal. I read a study that said because of the nature aspirin works, it lasts for 2-3 days and that studies have shown blood platelets remain less sticky even if taken every 2 days. It said it is still about 80% effective if taken once every 3 days.

For now I'm trying every other day and will continue monitoring my blood work. Fibrinogen is one platelet stickiness indicator so I'm monitoring that.

Markl60 profile image
Markl60

Hi sos thanks for posting these. May I ask what country are you based in and where did you get all these tests done.

Thanks

sos007 profile image
sos007Ambassador in reply to Markl60

I live in Canada. Here a physician gives you a blood-test requisition form and you take it to your lab of choice to have it completed. The labs will provide you with online access to your results. The two major labs in my local area are Lifelabs and Dynacare.

Since most of the tests I have completed are not covered by the government-run health insurance, I must cover the cost; so I tell my physician what tests I would like done and he fills them in on the form. Since my doctor recognizes that I am well-informed he will give me a nearly-blank requisition form with one covered test and allows me to fill in the rest on my own.

Markl60 profile image
Markl60

No Lp(a) test ?

sos007 profile image
sos007Ambassador

I that that I reported that test in my last post - June 28th update - it was 540 mg/l well above the 300 mg/l cut-off. I have taken this test 5 times now and I seem to be oscillating within a range from 510 on the low side to 769 on the high side. Given that this value is mostly genetically determined, I don't know if I'll ever be able to bring it below the cut-off level, although I'm continuing the Pauling Therapy in hopes of doing so. The interesting thing is my brother's level < 100 mg/l.

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