Switching from Cymbalta to Zoloft - Anxiety and Depre...

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Switching from Cymbalta to Zoloft

mer8 profile image

I'm sure this question has been asked before but I'm new here so I'd like to find out if anyone has any experience switching from Cymbalta to Zoloft? I used to love Cymbalta but after a number of years taking it, it has caused my blood pressure to spike to dangerous levels so I have to switch to something else. Zoloft is my psychiatrist's pick and he seems to think I can just start taking the Zoloft and discontinue the Cymbalta all within a week. Does anyone have any experience with this situation? I'd like to avoid the crazy Cymbalta withdrawal at all costs.

9 Replies

I haven’t taken Cymbalta but I have taken Zoloft. For me, (I had the liquid because I was younger) I had to always take it with food and I couldn’t have milk with it or I would get sick.

If you are taking pills, this may not happen. I just wanted to let you know and be careful!


mer8 profile image
mer8 in reply to weasel546

Thanks, I always try to take pills with food. Hope this helps with the transition

I never switched, but I take zoloft and never had any problems with it. I find it to be a good fit for me.

mer8 profile image
mer8 in reply to

Ok cool, I hear it's one of the oldest anxiety pills out there.

in reply to mer8

Yes, from what I researched it is.

My experience with Zoloft is that you have to slowly increase and that w cymbalta you would be tapering - ask Dr about that .

it may take a couple of weeks ,- when I was thinking of changing from Zoloft to Effexor that’s the way my dr was going to do it .

I think slower is better . ( I do know they are different category antidepressants )

mer8 profile image
mer8 in reply to Flowergigi

Thanks for the response. The psych ended up having me take the Cymbalta every other day while I built up the Zoloft over 5 days....then he had me quit cold turkey. It was one of the most awful things I've ever experienced and I was very close to checking into a hospital.

Been off Cymbalta about 5 days now and am finally feeling a bit better. Still having horribly anxious moments and lots of nausea but they gave me a benzo for that. I hate taking them yet sometimes its all I can do to make it through.

Ramon123 profile image
Ramon123 in reply to mer8

I know this post is a year old, but when did you start feeling better after the Cymbalta?

I’ve been going fiends on Zoloft 25 mg every two weeks and going up on Trintellix 5 mg every two weeks and praying this works

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