PSA Rising After Taxotere and balance, strength and tearing are bad.

[alperk]

Completed 5 months of Taxotere 1/10/25 and stopped Orgovyx and Prednisone (iADT) on 1/23. PSA dropped from 15.5 to 0.07 on 2/20 but rose to 0.17 on 3/20. Don't like the doubling time. MO appt is 4/27 following 4/20 blood test. Assuming continued PSA rise I expect to be back on ADT and also getting a PSMA scan.

Taxotere side effects were OK until last 2 months of treatment. Balance and strength are pretty terrible now. Going to Balance and Strength classes 6 times a week but not noting significant improvement.

Also watering eyes are constant issue. Hopefully this will resolve with time.

[Eggdoc]

The taxotere caused my eyes to water and I saw an ophthalmologist who unblocked my tear ducts in the office. (he said sometimes you have to go to OR for light anesthesia if he can't do them in the office). It's a minor but REALLY aggravating side effect. I rec seeing eye doc asap. The balance may be due to your lack of hydration. I started getting an extra liter of IV fluid before and after the infusion and this helped my balance.

Sorry for the increase in PSA - very disconcerting. Keep positive and be aggressive with pursuing treatment. I'm not sure if the Pluvicto has a role now, but I always try to be prepared with what I will do "if" my current treatment is unsuccessful. It's worth discussing with your MO

[alperk in reply to Eggdoc]

Thanks. MO appt 4/17. Will post next steps for info

[Vangogh1961]

Watery eyes also related to eyelash loss, kits if tearing for me.

Why did you stop ADT if it was working?

[j-o-h-n]

So Al we are in the same boat........ I'm 88 and my balance sucks...... but my eyes are dry, not wet.......

Note: if you're falling try to protect your head....

Good Luck, Good Health and Good Humor.

j-o-h-n

[alperk in reply to j-o-h-n]

Thanks. I always look forward to your refreshing comments. MO appt 4/17 so I expect some action to report.🙏

[j-o-h-n in reply to alperk]

May your "action" report be a nothing burger.

(note: Use a good cane, maybe the one you use to beat your wife🤡)

Good Luck, Good Health and Good Humor.

j-o-h-n

[alperk in reply to j-o-h-n]

Thanks. Actually I bought trekking sticks and they give me better balance, stride and walking speed. As I progress through my 6 per week balance and strength classes, I hope to graduate from the sticks.

[j-o-h-n in reply to alperk]

Do you think I could use a pair of pool cues instead? Also, does it help that I used to be a good 9 ball shooter (hustler)? Rack 'em up there Minnesota Newman.

Good Luck, Good Health and Good Humor.

j-o-h-n

[God_Loves_Me]

Are you taking Zytiga or nubeqa with Any ADT ?

[alperk in reply to God_Loves_Me]

5 months of docetaxel was over 1/10/25. MO had stopped Xtandi 1 month into chemo-not sure it was doing any good and had some reaction to docetaxel. Went on iADT 1/23/25 so no Orgovyx nor prednisone. Seeing MO 4/17 and will publish the plan for future.