PSA still rising despite Taxotere rec... - Advanced Prostate...

Advanced Prostate Cancer

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PSA still rising despite Taxotere rechallenge

dockam profile image
15 Replies

Hey gang,

Had 6 Taxotere chemos ending in April 2021. Had 15 in 2015. An Axumin scan showed that the 2 x

1cm iliac lymph nodes had reduced uptake 😊

PSA hit a three year low at 2.2.

Then monthly PSA: 2.3, 2.6, 3.6, and this month 5.5😔

Awaiting the radiology department to get the Axumin scan approval.

It's a Rollercoaster ride with #stageivpca

Fight on y'all

Randy

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dockam
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15 Replies

Sorry to hear. Are you considering going on to Jevtana?

monte1111 profile image
monte1111

Never fear, Lu 177 is almost here. I'm trying to figure out how to be first in line.

ellie2211 profile image
ellie2211 in reply tomonte1111

is there an expected approval date?

monte1111 profile image
monte1111 in reply toellie2211

I'm not sure how this plays out. I just read an article saying they thought it would be sometime next year. Does FDA approval mean Medicare approval? How about insurance? What strings will be attached? What about sequencing? Others here are way more informed than I am. Even if you are PSMA positive, it doesn't work for everyone. We are all Guinea Pigs.

j-o-h-n profile image
j-o-h-n in reply tomonte1111

Just tell everyone "after me you're first"......

Good Luck, Good Health and Good Humor.

j-o-h-n Sunday 09/26/2021 3:57 PM DST

Shooter1 profile image
Shooter1

You've had your ups and downs, hope they find actionable spots on scan.. My Na-F18 scan showed what regular scans missed and they got Zapped.

tango65 profile image
tango65

Consider getting a liquid biopsy or a direct biopsy to determine the somatic (cancer) genome and see if the cancer may respond to olaparib, rucaparib or keytruda. If it were possible to get tumor cells they could do IHC studies and see if the cancer may respond to a combination of jevtana and cisplatin or similar.

If you did not get Provenge, you should discuss getting it. Provenge is the only vaccine approved for PC and it offers a survival advantage,

Personally I will pursue the biopsy, Provenge and a clinical trial with Lu 177 PSMA. Lu 177 PSMA has shown to prolong life and even more important quality of life.

This is a link to Lu 177 PSMA treatment trials and other theranostics:

clinicaltrials.gov/ct2/resu...

clinicaltrials.gov/ct2/resu...

clinicaltrials.gov/ct2/resu...

Spyder54 profile image
Spyder54 in reply totango65

Tango, always good input. Thank you Brother.Best,

Mike

tango65 profile image
tango65 in reply toSpyder54

Best of luck on your journey.!!

erjlg3 profile image
erjlg3

Praying Randy🙏! Fight fight fight❤

Spyder54 profile image
Spyder54

Randy check out TA’s post on Lynparza and Zytiga (Abi). Works for most. Not just BRCA+.You never know what may work w your chemistry.

Yes, Fight On Brother,

Mike

Haniff profile image
Haniff

Randy,

Don't let the numbers get you down. I noticed you're testing PSA every month, perhaps you may want to take things a notch or two down and stay positive. So smile and enjoy the present. I hope you're still out there running but in a safe way 😷

Ahem...now for myself as you are aware, I am also rechallenging docetaxel. The numbers did not come down very well but my oncologist and me are not fretting. Instead, i have completed 6 cycles and the PSA is at 24 from 35 when I first started infusion 1. We, as in my onco and I, have decided to push the cycles to 4 more that means 10 in all to try and bring the PSA down further since she says I look alright and seem to tolerate the cycles very well. I am still on 3 monthly Lucrin/Lupron jab, and taking steroids every day. I don't let the numbers control my life, just taking things easy and staying happy.

So, here goes nothing. It will be the first time I am going to cross the 6 cycles line and praying for the best. One good day at a time.

My best to you Randy ❤️

Haniff

Magnus1964 profile image
Magnus1964

Keep up the good fight. My prayers are with you.

j-o-h-n profile image
j-o-h-n

Randy, you're a cool guy (now called dope - slang) and I hope for the best for you!!!

Good Luck, Good Health and Good Humor.

j-o-h-n Sunday 09/26/2021 4:07 PM DST

monte1111 profile image
monte1111

Just about choked on that one. Have you no shame sir?

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