Platinum Rechallenge + Atezolizumab for Recurrent SCCP

[Andy2025]

Hey everyone,

My dad's cancer recently recurred. His initial diagnosis was small cell cancer of prostate (SCCP) which was treated with cisplatin and etoposide. After treatment, his cancer relapsed and the new prostate biopsy showed adenocarcinoma, but a new biopsy from a lymph node has now confirmed that it's small cell again.

For treatment, the doctor is suggesting a platinum rechallenge since the first-line treatment worked well, and the recurrence happened after 180 days. From what I have read, the standard second-line option is Topotecan for SCLC ( lung), but I believe there is a study showing that platinum rechallenge is more effective in this situation ( SCLC)

In addition, the doctor wants to add Atezolizumab, since it showed efficacy in the first-line setting.

Just wondering if anyone has experience with platinum rechallenge vs. Topotecan or adding Atezolizumab in second-line treatment? Would love to hear any thoughts or experiences.

Thanks!

[GP24]

Just want to let you know that there is a new drug in clinical trials which seems to be active in neuroendocrine tumors. The name is Mevrometostat. urotoday.com/video-lectures... You could contact Dr. Schweitzer from Fred Hutchinson Cancer Center, Seattle and ask if he would treat your father.

[j-o-h-n]

AI Overview

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Keytruda Indication for Metastatic Small Cell Lung Cancer ...

Keytruda (pembrolizumab) was a treatment for metastatic small cell lung cancer (SCLC) until Merck voluntarily withdrew it from the US market in March 2021. The withdrawal was made in consultation with the FDA.

Explanation

Keytruda was approved for the treatment of SCLC in 2019 based on tumor response rate and durability of response.

The FDA required overall survival (OS) data to confirm Keytruda's use in SCLC.

The KEYNOTE-604 phase 3 trial met one of its primary endpoints, progression-free survival (PFS), but did not meet the OS endpoint.

Merck withdrew Keytruda for SCLC in patients who had experienced disease progression after platinum-based chemotherapy and at least one other line of treatment.

Keytruda is still used to treat other types of cancer, including non-small cell lung cancer and head and neck squamous cell carcinoma.

Good Luck, Good Health and Good Humor.

j-o-h-n