Experiences with

Atezolizumab

Atezolizumab is a monoclonal antibody that was approved by the US Food and Drug Administration in 2020 for the first-line treatment of adult patients with metastatic NSCLC. https://www.iaslc.org/iaslc-news/press-release/lcmc3-neoadjuvant-atezolizumab-safe-meets-primary-endpoint-pathologic

The plan and probably my last chance is for Atezolizumab immunotherapy which I start next week. I thought it would be Keytruda but he said the above was better for my circumstances. Does anyone have any positive results to the above treatment please or experience of having this drug.

I’ve been on a clinical trial of a combo of Cabozantinib and Atezolizumab for three months now. It’s a combination of pill and infusion. My Mets that involve my lungs, liver and lymph nodes are staying in check. But my PSA climbs 20 spots every three weeks of my treatment.

The Mayo Clinic has accepted me to get either cabozantinib (XL184) alone or in combination with atezolizumab (immunotherapy). Cabozantinib is an oral agent which is great and is FDA approved for medullary thyroid cancer. This is a phase 2 study.

My body has been beat up by 9 cycles of chemotherapy so far this year, not to mention atezolizumab which faield. I really was hoping for some form of remission to allow my body to recover and get healthy again before having to continue the fight.

In other news, I completed chemo back in June, finished radiation in July, and continue on Atezolizumab, Lupron, Abiraterone, and Xgeva. I'm finally beginning to see glimpses of improving health as I recover from the chemo and radiation.

Oddly, for such an aggressive cancer, it actually has a low mutational burden which explains why the atezolizumab didn't work. As I understand it, my cancer isn't different enough from my healthy tissue for my immune system to care.

I had 12 consecutive weeks of Ptaxil, Carboplatin and either a placebo or Atezolizumab (pretty sure it's the Atezolizumab). I just started my 4 dose - 2nd round of Doxorubicin, Cyclophosphamide and placebo/atezolizumab 2 weeks ago....Lord, that was a rough ride for 7 days after!

Part of my cocktail includes Atezolizumab which is an immunotherpy agent. I found my blood counts for the last two cycles interesting, and thought I'd share to see if anybody else has seen anything similar or has comments to add.

Atezolizumab - Vemurafinib - Cobimetinib. Ryan did not fair well on a dual therapy, so I’m not sure if that will be the course of action. Definitely has to be discussed. Once the bowel heals and functions correctly he will be able to eat without restrictions and go back to normal life.

Plan includes Cisplatin, Etoposide and an immunotherapy add of Atezolizumab. Seeking any positive experiences, tips on dealing with side effects, etc. Hope you’re all enjoying your Sunday. Best, Leo

I'm currently on carboplatin, etoposide, and atezolizumab for neuroendocrine prostate cancer. Scans done before the third infusion showed shrinkage of the tumors in my bladder and liver. To enhance the side effects, I also got lupron and xgeva injections at the end of the first week.

[1] Bottom line: no add-on value or synergy for Atezolizumab (a checkpoint inhibitor) with Enzalutamide. "Patients treated with atezolizumab (Tecentriq) and enzalutamide (Xtandi) had a median OS of 15.2 months as compared with 16.6 months for single-agent enzalutamide.

Tecentriq (atezolizumab) being available as a first line immunotherapy option for NSCLC gives patients more options for first line treatments than ever before.

This study will compare the effects, good or bad, of atezolizumab plus bevacizumab versus active surveillance (not receiving any study treatment) on patients with completely resected or ablated HCC who are at high risk for disease recurrence Patients will be put into two groups or Arms of the study:

Focusing on clinical trials of atezolizumab, a common immunotherapy treatment for non-small-cell lung cancer (NSCLC), the Australian cancer researchers found improved responsiveness to the drug in those with a high body mass index (BMI). https://medicalxpress.com/news/2019-12-high-bmi-cancer-survival.html

I am starting Atezolizumab and Abraxane has anyone been through this regimen and did you have side effects

My MO wants to start chemo again or another clinical trial combo of Cabozantinib-Atezolizumab. I wish they would come up with easier names of these drugs. I have to be off my last trial for four weeks to start this new adventure. The side effects like my last trial are debilitating.

Every third treatment I receive the aforementioned as well as carboplatin and either the placebo or the trial drug, atezolizumab. I had grown my hair very long in the past few years.

Atezolizumab, Etoposide, Carboplatin They’ve also collected blood to send for Tempus ?? Study or trial? Will she lose her hair? Did you find anything helpful with side effects of any of these? Just trying to get more information. With gratitude!