Experiences with

Atezolizumab

Hi all, I’ve read online that some sclc patients are getting atezolizumab immunotherapy by injection. It was first used in March 2024 in Newcastle. There doesn’t seem to be much other information.

https://www.urotoday.com/conference-highlights/esmo-2024/esmo-2024-prostate-cancer/154863-esmo-2024-cabozantinib-plus-atezolizumab-versus-2nd-novel-hormonal-therapy-in-patients-with-metastatic-castration-resistant-prostate-cancer-final-overall-survival-results-of-the-phase-iii-randomized-contact-02-study.html

MO wants to use Keytruda but it failed in trials isn’t Dostarlimab or atezolizumab better?

In early trials, combining ciforadenant with atezolizumab has shown promise, especially in patients identified with an “Adenosine Gene Signature,” a biomarker for treatment response. This strategy offers new hope in overcoming prostate cancer’s immunotherapy resistance.

Atezolizumab, venetoclax, and obinutuzumab combination in Richter transformation diffuse large B-cell lymphoma (MOLTO): A multicentre, single-arm, phase 2 trial. [i]The Lancet. Oncology[/i], S1470-2045(24)00396-6.

Atezolizumab (Tecentriq): Atezolizumab is a checkpoint inhibitor that targets PD-L1 (programmed death-ligand 1). It has been studied in combination with other therapies for advanced prostate cancer in clinical trials.

I was treated with 4 rounds of atezolizumab/carboplatin/etoposide (chemotherapy and immunotherapy). A pet/CT scan shows it was effective, and I fared better than I expected going in, but definitely have fatigue and weakness.

I have the CDK12 mutation which is apparently known to be a drug target or to predict sensitivity to Atezolizumab (Tecentriq PD-1 Checkpoint Inhibitor), hence there is open Immunotherapy trial called BoB (NCT03767075). I meet the trial doctor next week.

108464 [i]Another Prostate Cancer Screening Candidate Outperforms Standard PSA Testing: Multiparametric Stockholm3 avoided far more unnecessary biopsies without sacrificing sensitivity, January 28, 2024:[/i] https://www.medpagetoday.com/meetingcoverage/mgucs/108457 [i]Cabozantinib Plus

Treatment with atezolizumab, bevacizumab, paclitaxel, and carboplatin (ABCP) was significantly more effective than pemetrexed plus carboplatin or cisplatin https://dailynews.ascopubs.org/do/atezolizumab-bevacizumab-and-chemotherapy-improves-pfs-egfr---alk--mutated-nsclc-after?

In May of 2022, with my 15-3 at 70, he wanted to put me in a trial for XL092 alone or with ATEZOLIZUMAB - Tecentriq. At this time, I asked for testing to make sure my original dx had not changed. The only test he did was for the P13k mutation, which came back neg.

Looking for a bit of advice re my mum who is based in the uk At 77, She was diagnosed with stage 4 lung cancer in Dec 2022, with g12c mutation January she started Atezolizumab.

https://www.urotoday.com/video-lectures/asco-gu-2024/video/mediaitem/3890-contact-02-phase-iii-trial-findings-on-cabozantinib-atezolizumab-combination-in-mcrpc-neeraj-agarwal.html

Current Medical plan is to undergo immunotherapy (Atezolizumab + Durvalumab) and chemo (Carboplatin + Eto poside). In spite of all these, she is in great spirit, willing to fight it out.

Now I'm on carboplatin, etoposide and Atezolizumab- chemotherapy and immunotherapy. The following article from Healthline is a great description of what took place, and possibly why.

Her lung tumor is currently stable and I want to get options if her current immunotherapy (atezolizumab every three weeks) becomes ineffective. There are several chemotherapy options, such as lurbinectedin (she was in a clinical trial for this drug, but was not selected to receive the drug).

Cabozantinib plus atezolizumab showed promising antitumour activity in patients with metastatic castration-resistant prostate cancer after novel hormonal therapy with an acceptable safety profile, supporting further evaluation of this combination. https://www.thelancet.com/journals/lanonc/article/PIIS1470

My husband has just had his second infusion of Atezolizumab/Bevacizumab, and is feeling awful. The initial infusion caused fatigue and some sickness but he is now experiencing chills, a bad cough, sickness, lack of appetite. He feels if this reaction is repeated in future infusions he will stop.

Atezolizumab (Tecentriq) will shortly be assessed by the Scottish Medicines Consortium (SMC) for use in NHSScotland, and we have been invited to provide a Patient Group Submission for the medicine. We are therefore trying to gather some patient experience quotes.

Anyone with advanced breast cancer er/pr+, her2 neg, asked to do this trial? I am a bit concerned because I was dx with luminal A in 2016 and had a lumpdectumyin left breast. Found lymphnodes too. Had 12 rounds of chemo and 18 days of rads. Was on anastrozle until Dec of 2019 with progression, mets.