PSA rising. What could the next steps be?

[gio2x]

Hello everyone!

I hope you are doing well. I wanted to post an update about my father's current situation. After PSA started to raise, the MO added Abiraterone 1000 mg. a day with 10 mg prednisolone to his treatment regimen with Zoladex (once every 3 month) and Zoledronic acid (once every month). Abiraterone took his PSA from 70 to 8.97 in one month but after that every PSA test gives us increase in PSA number):

07/06/2024 – PSA 11.9

08/07/2024 – PSA 20.8

04/10/2024 – PSA 32

14/10/2024 – PSA 40

21/11/2024 - PSA 99.3

My father will have radiologic scans to see if there is visible cancer progression, The next steps will be decided after that. His oncologist mentioned possible chemotherapy (he had good response to chemotherapy previously), also changing abiraterone with enzalutamide might be a next step. He doesn't feel any additional symptoms yet but we know that if PSA keeps rising he might get pain in the bones, etc.

What do you think would be the best next step? Which sequence of treatment methods might give us the better results? Any suggestions and ideas would be much appreciated. Thank you.

[GP24]

I would try to get a Pluvicto treatment. us.pluvicto.com/

[God_Loves_Me]

Hello

I am NOT doctor and I am NOT medical advisor. Here are my suggestions, I think he has no physical symptoms.

- Try to find out ADC clinical trials like ARX517 that recently shared great result to public.

- AMG 509 immunology from clinical sites may be also good options