Any success stories with Provenge?

[Simonapo]

My Dad had a PSMA Pet scan that shows recurrence in prostate and 2 small spots on the spine at L2 and T8. He was On Abiraterone and Prednisone for exactly 3 years. Dr at City of Hope recommended adding Provenge and continuing Abi and Pres. Any success stories using Provenge with or after Abiraterone? His PSA is 0.029. Also his TMB (Tumor Mutational Burden) is low, which I thought it means it don’t respond to Provence treatment, but not sure? Anybody that has TMB low and had a good run with Provenge, please, please let me know. Thank you so much.

[pjd55d]

I was diagnosed in Feb 17 PSA 400 metastatic

immediately started ADT

PSA down to single didgets - and then slow increase

Did 3 sessions of Provenge Sept18 - noticable drop to undetectable or almost

I, and my Dr's think it worked well. The process - extraction and re-injection is long but - bring a book - or sit and chat - watch TV

good luck

[Simonapo in reply to pjd55d]

Thank you so much, so glad to hear you had a good response, thank you🙏

[Faithwalker]

It is not supposed to lower PSA, but in my case it did. PSA slowly riding before Provenge. Kept PSA down for about 3.5 years while I continued ADT before it started rising again. I think I’ve read it works better if PSA is low. We’re all different. I can’t predict what it would do for someone else but I feel like I got a 3 1/2 year extension from Provenge.

[Simonapo in reply to Faithwalker]

Oh my god! so good to hear that. You said you continue ADT, is that just Lupron? Thank you again.

[Faithwalker in reply to Simonapo]

I get Trelstar shots and am on Xtandi pills.

My PSA has climbed last 3 tests. Xtandi worked over a year and a half. Likely go on new plan soon. Provenge gave me a PSA no rise extension of over 3 years, but it wasn’t permanent. I am thankful for how it worked for me.

[Simonapo in reply to Faithwalker]

Thank you, wishing you best health 🙏

[Tall_Allen]

"Also his TMB (Tumor Mutational Burden) is low, which I thought it means it don’t respond to Provenge treatment, but not sure? "

No. You're thinking of Keytruda.

[Simonapo in reply to Tall_Allen]

Thank you so much Allen for your response. I really value your opinion, do you think this is the right treatment for him? The spots in T8 and L2 are very small with SUV of 3, but my concern is that there are also :” 2 foci of F-18 PYL activity. The first located in the anterior base is an SUVmax of 62.0 (image 417). The second located in the left posterior lateral mid body to apex with SUVmax of 15.1 (image 422).” I never heard of such a high SUV, is Provenge enough to deal with it? Should he continue Abiraterone even if doesn’t seem to work anymore, maybe will work again after Provenge? Or is it better to switch to Xtandi or keep that for later in case we don’t get a good response from Provenge and Abi? Sorry for all these questions. I really appreciate your knowledge. Thank you so much.

[Tall_Allen in reply to Simonapo]

I like Provenge+docetaxel+Xofigo

[Simonapo in reply to Tall_Allen]

Thank you Allen, I will suggest that, thank you so much.

[Faithwalker in reply to Simonapo]

I had Docetaxal about a half a year before I went on Provenge.

[Simonapo in reply to Faithwalker]

Good to know, thank you.