I completed the Provenge regimen in early November 2017. PSA measure on 120517 was 15.36 approximately double six months from six months earlier and before the Provenge. CT scan also revealed lymph node involvement. On 040918, CT scan lymph node involvement still present at approximately the same level. PSA was measured at 65.6. I understand that PSA generally increases following Provenge, but thought I should expect a decline six months later. Doctor has now ordered a bone scan and talks of adding Zytiga or Xtandi to current meds of Lupron every three months and daily Bicalutamide. Interested in learning of experience with Provenge. My doctor says it might still be working. I am skeptical. I was first diagnosed in 2010 followed by robotic surgery, pelvic radiation, and then Lupron. I am still vertical, but with low energy and pain.