Hello all,
Looking for input on the actual real-world results of Pluvicto. I’ve heard the horror stories about men whose cancer was seemingly under control after Pluvicto, only to explode back with a vengeance. Do any of you have a statistical analysis showing successes vs catastrophic failures?
from experience on the eclipse trial and reading up on others who did Pluvicto, most get some downward trend in their PSA. Unfortunately, it appears to be temporary.
Very true. I am not an expert but I believe that after wiping out the PSMA positive strains of the cancer the remaining PSMA negative strains take over. Therefore repopulation happen with either PSMA negative strains or maybe just strains who survived the radiation, lets say repopulation by to the radiation most resistant strains of the prostate cancer.
Again it is only my private opinion. Actually I don't really know.
Pluvicto offers a valuable treatment option for mCRPC, especially after other therapies have failed. However, like all treatments for advanced cancer, it comes with the risk of disease progression, and in some cases, this progression can be rapid and aggressive. It's essential to discuss the potential benefits and risks of Pluvicto with a healthcare provider, considering individual factors and disease characteristics.
If you're considering or are on Pluvicto, it may be helpful to stay closely monitored and have a clear plan with your oncologist for managing any potential progression.
I was in a clinical trial with Pluvicto and received 5/6 treatments, last one Nov 2023. Side effects were minimal, but my PSA was already undetectable by the second infusion. However, I think the heavy work in lowering the PSA was from hormone therapy which started before the first treatment (PSA went from pre-treatment 49 to 0.16 on the day of the first treatment).
PARP inhibitor Olaparib, phase 3 study findings (PROpel)
MRI prior to HDR Brachy and HDR intensity.
