pluvicto + docetaxel

[God_Loves_Me]

Disclosures:

I am not a doctor or a medical advisor. My views are personal, and I post them here for discussion and learning purposes. Do NOT STOP Or HOLD your treatment.

Why Am I posting here?

I am posting here to discuss all opportunities with the doctor and learning purpose only.

I am searching for warriors who took Pluvicto + Docetaxel. If you did, please let me know about your experience, including the side effects and dosage of docetaxel.

Here is my example :

20mg docetaxel + Pluvicto

1 full dosage of docetaxel + 6 full cycles of pluvicto

Top Questions

Why did your MO recommend two combinations?

What kind of scan has been done during your treatment? Your insights could be really helpful for me.

Does a lower dosage of docetaxel turn cancer into docetaxel resistance?

Even if you have any combinations with Pluvicto, please share them with us.

[Tall_Allen]

20 mg is a very low dose of docetaxel - are you sure that is right? Docetaxel is usually 75 mg/m2 every 3 weeks for 6 cycles. When used with Xofigo, they reduced it to 60 mg/m2 every 3 weeks for 10 cycles.

[God_Loves_Me in reply to Tall_Allen]

Ok 20mg is just example

[Tall_Allen in reply to God_Loves_Me]

Example of what? So you are not getting docetaxel+Pluvicto? I don't understand the purpose of this thread.

[God_Loves_Me in reply to Tall_Allen]

The main purpose of the thread is to find someone who did docetaxel+Pluvicto together.

My biggest worry is that pluvicto may fail. Dr just wants to do Pluvicto and I am trying to add Docetaxal in way that adds more success percentage in Pluvicto

[God_Loves_Me in reply to God_Loves_Me]

Next goal is to talk dr for 60 mg/m2 every 3 weeks for 10 cycles with Pluvicto

[Seasid in reply to God_Loves_Me]

Probably your blood work would not allow you to go through all the cycles. That is always a biggest problem.

[God_Loves_Me in reply to Seasid]

100% Agree

[Tall_Allen in reply to God_Loves_Me]

I don't know of any such clinical trials. I doubt a doctor would do that outside of a clinical trial.

[dentaltwin in reply to Tall_Allen]

Dayum! Just learned ANOTHER thing from you. I had no idea dosing of chemo was at least sometimes based on surface area (I certainly never heard that when my wife was on chemo). Then today saw an article on Medscape about a new formulation for pancreatic cancer and saw that dosing method again--thanks!

[Seasid]

Brysonal had 3 cycles of Pluvicto followed by 3 cycles of docetaxel. You can see his profile. I find it reasonable.

[Seasid in reply to Seasid]

Brysonal's profile:

healthunlocked.com/user/Bry...

[Seasid in reply to Seasid]

More info about Pluvicto and Docetaxel:

healthunlocked.com/advanced...

[God_Loves_Me in reply to Seasid]

Thank you great example

[chipspesto]

I received Docetaxel one year before getting six cycles of Pluvicto. My bone marrow took a hit ; low blood counts, low platelets, fatigue, muscle loss.

PSA now .03 , MO says it will start rising again in about six months; still weak but getting stronger.

I do not believe my system could stand taking Docetaxel and Pluvicto at the same time.

You might be stronger, best to you.

[God_Loves_Me in reply to chipspesto]

Agree my system will not take it as well. Does your MO design your treatment plan as one Docetaxel dosage and then six Pluvicto cycles?

[chipspesto in reply to God_Loves_Me]

My treatment was the following ;

---Six cycles of Docetaxel ending 6-22 with PSA 3.2 ;

---Next six months at 12-22 PSA rose to 132;

---Started Jevtana on 1-23 for eight cycles ending 6-23 with PSA at 63;

---Pluvicto started 7-23 ending 2-24 with PSA at .03;

Results better than Chemo, but I know it's not a cure.

Best to you

[ETCP]

Not docetaxel but husband just started a trial on Wednesday of 1st dose of Carboplatin (1/2 dose) given every 3 weeks and Thursday he got Pluvicto which will be given every 6 weeks.

[God_Loves_Me in reply to ETCP]

Does he had docetaxel ? What’s trial number ?

[ETCP in reply to God_Loves_Me]

He started with Triplet Therapy (lupron, Abiraterone, Docetaxel) in March 2022.

This trial is 23-693.

[TeleGuy]

If you are looking for a combination that enhances Pluvicto, enzalutamide increases PSMA expression, theoretically making the Pluvicto more effective. I’m doing that and will report when I have a chance.

[God_Loves_Me in reply to TeleGuy]

Please update the result

[ETCP]

update my husband has had 1 dose of Pluvicto and 2 doses of Carboplatin over the last 6 weeks. 3rd chemo and 2nd Pluvicto will be 7/24 and 7/25. So far so good his PSA started at 90 and is down to 25. All other numbers are good except ALP is starting to creep up. He has 5-7 days of nausea after treatment, he has some increased aches and pains still nothing that doesn't resolve with Tylenol. Fatigue continues to increase but he fights through it.

How is your treatment going?

[God_Loves_Me in reply to ETCP]

treatment going well, I would say request dr for Benadryl IV before infusion it will reduce other side effects immediately . I am doing clinical trials call ARX517