New way to delay resistance in prostate cancer

[Maxone73]

In vitro/in vivo but ready for clinical.

I have found and tried to read the paper...what I understood is "great news!" but don't ask me to explain better than this:

Prostate cancer treated with androgen deprivation therapy (ADT) can (will) develop into castration-resistant prostate cancer (CRPC), making ADT basically useless. Researchers found that this progression is associated with an accumulation of immunosuppressive cells like tumor-associated macrophages (TAMs) around blood vessels, which suppress the body's anti-tumor immune response. So in one sense this is a predictive factor of "imminent" onset of resistance to castration. Researchers discovered that these TAMs exhibit immunosuppressive markers and reduce the activity of crucial immune cells. By using lipid nanoparticles (LNPs) coated with an antibody to deliver a STING agonist directly to these TAMs, they induced the production of interferon beta (IFNβ), thereby activating CD8+ T cells and delaying CRPC onset.

So it's not a cure or a new therapy per se, but can be useful to delay castration resistance (or maybe even invert it, but the article does not talk about it).

"Taken together, our studies show that LNP delivery of cGAMP to PV TAMs in ADT-treated prostate tumors increases antitumor immunity and delays CR. If reproduced in patients with prostate cancer, it could extend their treatment window for ADT and limit the metastatic spread of their disease."

As the lead researcher, dr Lewis, I hope for a clinical trial ASAP! Our main aim now is to resist till science gets good enough 😉

jitc.bmj.com/content/12/7/e...

[Justfor_]

The key word here is "accumulation", that is a cummulative mechanism. Feed it with mega doses of ADT and the critical point is reached earlier. More is NOT better.

[Sandy752]

Maybe I am missing but I don't see any time elements in this article. I went on Lupron (every 4 months) 10 years ago after radiation failed to cure me. Oncologist said I would be on it for life even if extra meds were added. PSA is currently 0.48.

[Maxone73 in reply to Sandy752]

I think it’s too early for that, they are still in vivo and in vitro

[RMontana]

This is what I have found regarding IHT (intermittent hormone treatment) and CRPC. See this study.

healthunlocked.com/active-s...

The take away; There are some counterindications in this podcast regarding TET therapy and its impacts, especially in the 1st year of ADT treatment. Its important to see the results of the one study posted but the implications from this presentation are clear; higher TET is not protective during the 1st year of ADT…afterwards it appears that intermittent treatment with its introduction of TET, does not appear to affect OS and can improve QOL.