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Advanced Prostate Cancer
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Common prostate cancer treatment tied to dementia, study shows

Common prostate cancer treatment tied to dementia, study shows

knowridge.com/2017/12/commo...

"A common hormone therapy to treat prostate cancer may double a man’s risk of dementia, regardless of his age, Penn Medicine researchers reported in a study published in JAMA Oncology.

Recently, researchers discovered a dramatic association between Alzheimer’s disease and androgen deprivation therapy (ADT), a mainstay of treatment for prostate cancer since the 1940s currently used in over a half million men in the United States.

This study suggests a broader neurocognitive risk associated with the testosterone-lowering therapy"

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I suspected that years ago; that among cardio vascular issues is why I delayed ADT for 18 years. Doctors wanted to put me on it in 1999. I took my first Lupron injection this year. There comes a time when you don't have a choice, if you want to live more years.

Rich

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And many more you will!

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Thank you. My goal is to be a marathon man, 26 years. I hope, you too will achieve that goal. Let us enjoy life.

Rich

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PS: I hit 19 years this month, when it was determined my PSA indicated PCa.

Rich

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Awesome stretch! We’re you on WW during that period?

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radiation,72Gys; later cryosurgery, since 2004 ww. my key was clear scans and doubling time less then 6 months. I went from PSA 17 to PSA 27 range; until scan showed tumor in pelvic lymph nodes.

Today scans are clear.

Rich

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Fantastic...

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Personally ADT evokes mental fog ......my , memory and cognitive skills have fallen off a cliff. I agree with the findings. I thought it was just me. Thank you.

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"Personally ADT evokes mental fog"

Have you tried vivelle estradiol patches?

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No I have not. I’ve heard of them however. Something to look into. Thank you.

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Yes. You may find that to be a game changer for you.

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I do not know if it helps mental clarity, probably does.... I am taking estrogen transdermal gel ("estrogel" brand is best imho) AND progesterone cream. I found I needed BOTH to get a result estrogen alone did not cut it

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Most likely the same at the vivelle estradiol patches

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GEL is markedly less expensive than the patches, in my experience

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I agree also about the fog and forgetfulness. I an no longer able to balance my check book and have lost hundreds in bank charges.

From now on I will use money orders since there is no watching and waiting for checks to come in.

It's weird, I felt good yesterday and even went out in the cold to put up Christmas lights but today am so dizzy I can barely walk. Time to stay in!

Hang in there brother!

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Yes Sir buddy

I plan my day after the coffee. Each day is a new challenge. Don't know weather I'll be motivating in a Porsche or Preis.

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My dad lived to be 97, and did not die from his prostate cancer. Docs could not find a cause, actually.. He took hormone therapy shots from 1999 to 2009, and didn't get dementia. He had a higher PDA than my husband, who has a low PSA (5) & yet my husband has 4th stage cancer that has metastasized into his lymph nodes. He takes Lupron shots, Zytiga, and now is diabetic (takes insulin shots)..and cannot take the prednisone (with the Zytiga), because it made his sugar over 600! Husband was one of the lucky guinea pigs for a newer drug now named Ibrance that worked 2.5 years. Took PDA down to 0, but now climbing again slightly. Every case is different. Docs think he is more likely to die from diabetes or a heart attack, so he is watching his diet now.

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Spell check kept making PSA PDA!

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My spel check is not warking...

j-o-h-n Saturday 12/09/2017 12:53 PM EST

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Yep we all tend to get what we call brain fog---short term memory, or difficulty finding a word.

Treatment: Acetyl L-Carnitine, doing crossword puzzles, playing Bridge or Chess---exercise the brain.

Nalakrats

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thanks

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To Nalakrats: I just ordered Acetyl l-carnitine from Amazon. We used to take arginine from LEF until I began rubbing off skin while bathing. We both need SOMETHING to cross that brain barrier. By the way, are you aware of a positive result so far from the BIRM? How much are you taking? Are you buying that from Amazon? As for chess, I can’t make Les play; for that I need my dad. But we are still discussing New Yorker articles. I want him to read the current one on infidelity. Not about us, please God, but rather about the slew of people losing their careers because of it. Interesting viewpoint by Zoe Heller. Mrs. S

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The data I have accumulated---is why would the NIH give a major 7 figure grant to the University of Miami Medical School, for studies as to not cancer---but specifically to Prostate Cancer. It was a natural treatment for HIV, from 1998 to 2002---then the pharmaceutical Industry won with its AZT--and millions of dollars campaign. It was presented at 2 Aids World Symposiums in 1998, and 2001.

And read the comments on Amazon, all of them from those that commented on its use. Also you can ask a question, at Amazon, to the users, such as describe what BIRM has done for you? This is all empirical/suggestive data, but enough for me to add it--as it does no harm---just costs money.

Now there is a 7X concentrated version---you can get that is suppose to really be beneficial for those with 4th stage cancers, as reported from Ecuador---who knows?---I have never used it, as I am keeping that option open for ---if I needed it--so I do BIRM maintenance, with the single strength product---the 7X has to come from a California distributor, or directly from Ecuador.

All I can tell you about BIRM--I follow instructions---I take 2 CC's twice a day---it says with food or Beverage---but I do it on an empty stomach, and maybe sip an ounce of water behind the syringe I use to squirt down my gullet. It is nasty tasting---but I got use to it.

Nalakrats

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Reply to Nalakrats

If I’ve made you revisit old turf, I sincerely apologize. We agree that the grant to the U of Miami medical school is positive, preliminary evidence as are the anecdotes about BIRM in Amazon reviews—well, many of them.

Mostly we were interested in how YOU are feeling taking BIRM twice daily. You appear to be thriving, thank God.

As for Leswell’s supplements, we are keeping the BIRM option open. We can’t remember the last time we had a cold and never the flu. Our immune systems seem to be functioning well thus far.

Btw, I did begin a subscription for the l-carnitine.

Our biggest immediate concern is his chemo or TRUS-caused bilateral lymphedema, especially in the left leg. The past couple months he has developed a swelling just above the groin which is sometimes hard and painful but, with massage, gurgles and softens, and the swelling goes away temporarily. When in the swollen stage, it feels more like a soft-boiled egg than tumor. I should probably post this PCa-related problem in another post.

Right now, I’ll restrain myself, cut you loose, and join Leswell at the TV throne. We ordered seven tiny brass bells from Lee Valley today for our niece and two nephews’ children, table favors they can keep for their Christmas trees someday.

May bells ring for you and all those who are contributing so much of yourselves to the rest of us.

Leswell and spouse— since you prefer to remain annonymous

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Yes--anonymous to most---but some know me--actually having lunch with one face to face next week---expect--a full technical session.

Nalakrats

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based on my own experience and others I have talked to, I think this is commonplace, not rare, unfortunately.....there is even a phrase now, "lupron brain"

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My husband has recently been diagnosed with mild dementia per brain MRI and cognitive testing. There is also suspicion of Parkinson’s and he will have more consults for that.

He was only on ADT for 2.5 years of his 17 year PCa journey and then had orchiectomy so I don’t know if we can blame ADT for the mental drop off. This may alter his treatment plan as he is 75.

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