Quercetin targets hnRNPA1 to overcome enzalutamide resistance in prostate cancer cells

[George71]

"The suppression of AR-V7 by quercetin resensitizes enzalutamide-resistant prostate cancer cells to treatment with enzalutamide. Our results indicate that quercetin downregulates hnRNPA1 expression, downregulates the expression of AR-V7, antagonizes androgen receptor signaling, and resensitizes enzalutamide-resistant prostate cancer cells to enzalutamide treatment in vivo in mouse xenografts. These findings demonstrate that suppressing the alternative splicing of the androgen receptor may have important implications in overcoming the resistance to next-generation anti-androgen therapy."

ncbi.nlm.nih.gov/pmc/articl...

[cujoe]

Thanks. Keep 'em coming, George. Be Well - cujoe

[pjoshea13]

George,

There was a thread on this 2 years back. Such a jolt to see posts from Neal & Dan:

healthunlocked.com/advanced....

-Patrick

[George71 in reply to pjoshea13]

thanks,

hopefully everyone knows of the benefit of taking Quercetin.

I would think taking Quercetin before becoming CRPCa would help delay or even prevent resistance to enzalutamide

[George71 in reply to pjoshea13]

"Such a jolt to see posts from Neal & Dan" ???

[pjoshea13 in reply to George71]

No longer with us. Very active in the group. Great guys. -P.

[George71 in reply to pjoshea13]

I was afraid that was what you meant -- very sorry to hear

[George71 in reply to pjoshea13]

Did PCa do it or something else -

[pjoshea13 in reply to George71]

PCa or complications thereof.

[George71]

Thanks,

that is hard to read

[rococo]

Can’t decipher what dose of queracitin from study.

[George71 in reply to rococo]

The nutrient mixture (NM), prepared by VitaTech (Hayward, CA) was composed of the following ingredients in the relative amounts indicated: vitamin C (as ascorbic acid and as Mg, Ca, and palmitate ascorbate) 700 mg; L-lysine 1000 mg; L-proline 750 mg; L-arginine 500 mg; N-acetyl cysteine 200 mg; standardized green tea extract (80% polyphenol) 1000 mg; selenium 30 μg; copper 2 mg; manganese 1 mg

[George71 in reply to rococo]

Quercetin according to Life Extension:

"an adjuvant prostate cancer dosage is 1,000-3,000 milligrams daily. (The lower dosage of 500 milligrams daily is currently being tested in a double-blind, human clinical trial on the effect of quercetin on the rate of increase in PSA and on the incidence of prostate cancer, but these results are not expected to be available until 2014 [Bischoff 2012]). "

[Manilo in reply to George71]

thank you. I take 500 mg to 1000 mg daily. Together with 50 mg of Zn.

Will consider increasing a bit.

[rococo]

Thanks George..Been taking it while I m stilll xtandi sensitive to ward off insensitivty. Will check my dose, What’s a person to do, Rocco

[George71 in reply to rococo]

along with Quescetin you may consider taking Boron 9 mg daily / D3 10,000 and K2 among your other supplements -- and see about adding Avadart if you aren't already taking it.

see here;

lifeextension.com/Protocols...

and here:

lifeextension.com/Protocols...

lifeextension.com/Protocols...