Statins: new study regarding time to ... - Advanced Prostate...

Advanced Prostate Cancer

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Statins: new study regarding time to CRPC

noahware profile image
14 Replies

Quite a few statin posts in the past few months... not sure if this was among them, but is very recent. [Edited below] Hat tip to Richard Wassersug at LifeonADT.com for posting.

pubmed.ncbi.nlm.nih.gov/350...

Abstract

Background: Metabolic syndrome and its pharmacologic treatment can potentially influence the progression of prostate cancer in men receiving (ADT). We aimed to evaluate the association between metabolic syndrome and its pharmacologic treatment with time to castration-resistant prostate cancer (CRPC).

Methods: We identified 409 men with metastatic castration-sensitive prostate cancer receiving first line ADT from 1996 to 2014 at our institution. Researchers collated data on metabolic syndrome, statin use, aspirin use, and metformin use. Flexible parametric survival models were used to calculate hazard ratios of the association between metabolic conditions and time from ADT initiation to CRPC.

Results: During a median follow-up of 59 months, 87% men progressed to CRPC. Median time to CRPC was 19 months. Fifty-six percent of men met the definition of metabolic syndrome. Metabolic syndrome was associated with shorter time to CRPC . Importantly, in men with metabolic syndrome, statin use was associated with a slower progression to CRPC.

Conclusions: Our study suggests that metabolic syndrome is a risk factor for earlier progression from castration-sensitive to castration-resistant prostate cancer and raises the possibility that treatment, such as statin use, may slow the time to progression.

14 Replies
LearnAll profile image
LearnAll

Statins is one of 4 off label PCa drugs in CareOncology protocol. The other 3 are..Doxycycline, Mebendazole and Metformin.

dhccpa profile image
dhccpa in reply to LearnAll

Haven't heard much about Care Oncology in a while. Are they producing any results? I never see articles about them.

LearnAll profile image
LearnAll in reply to dhccpa

There is enough research about control of Metabolic syndrome and slowing of Prostate cancer. Pjoshea has provided lot of information about this connection of Metabolic syndrome and longevity in PCa men.How do I know whether I have Metabolic Syndrome ? Here is the list of 4 core symptoms of Metabolic syndrome (1) Belly circumference of over 40 inches. (2) High blood sugar (3) High blood pressure and (4) Low HDL cholesterol and High tryglycerides.

What can we do to control Metabolic syndrome ?

(1) Lose weight .Goal should be getting BMI below 24. Can be accomplished by mostly plant based, raw low calorie diet and burning maximum calories by daily physical exercise. I have been able to bring down my BMI from 26 to 23.5 by above mentioned interventions.

(2) Taking Statins or Red yeast rice caps. or Garlic to get Lipid profile in fully normal range.

(3) Controlling blood pressure by weight loss, low sodium foods, exercise and of course blood pressure lowering meds such as Losartan.

(4) Exercise lowers tryglycerides and very low fat diet does so too. HDL can be increased by regular exercise and a small, daily intake of Red Wine ( Not more than a small glass)

Now, the disclosure...The above mentioned info is not a prescription. Its only for informational purpose. Check with your doctor first.

dhccpa profile image
dhccpa in reply to LearnAll

Thanks. I have done all that and continue. I've dropped 34 pounds since 7/2019, cut 2-3 inches off waist. Blood readings all good. Was already walking 3 miles 5 days per week. Trying to do more resistance. Even doing boiling showers followed by freezing finish, FWIW.

MateoBeach profile image
MateoBeach in reply to dhccpa

Is worth very much! Good going.

dhccpa profile image
dhccpa in reply to MateoBeach

Really? Somebody brought it to my attention, and I said WTF. It's free, easy, just a little daily torture, but it's become a ritual.

lokibear0803 profile image
lokibear0803 in reply to LearnAll

Could you clarify for me, do we mean that one must have all four of these symptoms to have metabolic syndrome? Or is it that the more of these symptoms one has, the more likely it is that one can be diagnosed with metabolic syndrome? I would suspect the latter, but appreciate your thought on this.

LearnAll profile image
LearnAll in reply to lokibear0803

A rule of thumb will be...If you have 2 or more than 2 symptoms mentioned above..you most likely have Metabolic Syndrome. Waist measure ment vary for Cau casian and African American men it is More than 40 inches whereas for Asian Men it is more than 35 inches.

GeorgeGlass profile image
GeorgeGlass in reply to LearnAll

do organic red grapes raise HDL too?

LearnAll profile image
LearnAll in reply to GeorgeGlass

No. Its alcohol which causes increase in HDL.

GeorgeGlass profile image
GeorgeGlass in reply to LearnAll

Must be the fermentation effect of the red wine, huh?

LearnAll profile image
LearnAll in reply to GeorgeGlass

Lots of physical Exercise and some alcohol (red wine preferably) can increase HDL. Honestly, increase in HDL is effect of alcohol intake irrespective of type of alcoholic drink. Exact mechanism ..how alcohol causes increase in HDL is complex. But then, Alcohol intake comes with its own side effects such as liver toxicity etc.

GeorgeGlass profile image
GeorgeGlass in reply to LearnAll

Yep, I used to do heavy social drinking on weekends throughout my life, until I got cancer. Now I almost never drink but if I do, it's a beer or red wine.

Thanks for this study. I haven't seen it before.

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