#AskChatGPT : list of immunotherapy drugs for prostate cancer

[God_Loves_Me]

As of my last update in January 2022, several immunotherapy drugs have been studied or are currently being investigated for the treatment of prostate cancer. Here are some of the notable ones:

Sipuleucel-T (Provenge): Sipuleucel-T is an autologous cellular immunotherapy approved for the treatment of asymptomatic or minimally symptomatic metastatic castration-resistant prostate cancer (mCRPC). It is designed to stimulate the patient's immune system to target and attack prostate cancer cells.

Pembrolizumab (Keytruda): Pembrolizumab is a checkpoint inhibitor that targets PD-1 (programmed cell death protein 1). While not specifically approved for prostate cancer, pembrolizumab has been studied in clinical trials for advanced prostate cancer, particularly in patients with mismatch repair deficiency (dMMR) or microsatellite instability-high (MSI-H) tumors.

Nivolumab (Opdivo): Nivolumab is another checkpoint inhibitor that targets PD-1. Like pembrolizumab, nivolumab has been studied in clinical trials for advanced prostate cancer, often in combination with other therapies.

Ipilimumab (Yervoy): Ipilimumab is a checkpoint inhibitor that targets CTLA-4 (cytotoxic T-lymphocyte-associated protein 4). It has been investigated in combination with other immunotherapies or with conventional treatments for prostate cancer in clinical trials.

Atezolizumab (Tecentriq): Atezolizumab is a checkpoint inhibitor that targets PD-L1 (programmed death-ligand 1). It has been studied in combination with other therapies for advanced prostate cancer in clinical trials.

Durvalumab (Imfinzi): Durvalumab is another checkpoint inhibitor that targets PD-L1. It has been explored in clinical trials for various cancers, including prostate cancer, typically in combination with other treatments.

These are some of the immunotherapy drugs that have been studied or are currently being investigated for prostate cancer treatment. It's important to note that while some of these drugs have shown promise in clinical trials, not all of them have been approved specifically for prostate cancer by regulatory agencies like the FDA. Additionally, ongoing research may lead to the identification of new immunotherapy drugs or combination therapies for prostate cancer treatment in the future.

[Shorehousejam]

This is a great list, I saved . Thank you for posting

[TwilightZone]

Very informative. Had Provenge therapy last summer - appears to have helped.

[dhccpa in reply to TwilightZone]

How can you tell? I didn't think it gave any indication, just worked in a clinical trial at extended life for a few months. What did you see that made you think it had worked?

[dhccpa]

No sign of Dr. Gary Onik's in-house immunotherapy? He's down in Ft. Lauderdale doing his own thing.

[leo2634]

I had Provenge in 2019

[j-o-h-n]

Thanks for the list, BTW.....(see below):

Pembrolizumab (Keytruda): Pembrolizumab is a checkpoint inhibitor that targets PD-1 (programmed cell death protein 1). While not specifically approved for prostate cancer, pembrolizumab has been studied in clinical trials for advanced prostate cancer, particularly in patients with mismatch repair deficiency (dMMR) or microsatellite instability-high (MSI-H) tumors.

So far so good for my Melanoma metastasis to my lungs....

Good Luck, Good Health and Good Humor.

j-o-h-n

[Avanat]

My husband had Nivomulab, along with Docetaxel, as part of a Phase 2 clinical trial. Other than that treatment he has been on ADT (started with Firmagon but now Orgovyx). He has had no cancer progression and is doing pretty good. Either the chemo or the combo of chemo/immunotherapy has helped his keep his cancer at bay. Either way, we’ll take it!

[God_Loves_Me in reply to Avanat]

How was side effects with combo of chemo/immunotherapy ?

[God_Loves_Me in reply to God_Loves_Me]

What was dosage of docetaxel ?

[Avanat]

My husband tolerated the chemo fairly well but the immunotherapy caused two side effects, stomatitis (mouth sores) and colitis, so his oncologist took him out of the trial after 8 months. The trial was six cycles of Docetaxel every 3 weeks with immunotherapy about 30 minutes after chemo, then just immunotherapy alone every 3 weeks. The immunotherapy was to last a total of 24 months but was stopped before his side effects could become permanent. I’m happy to report they did finally go away but it took awhile. As for the dosage, I don’t know what it was but will check his records and let you know.

[God_Loves_Me in reply to Avanat]

Great insights. Thank you for sharing details.