Study on anti prostate cancer properties of honey

[Graham49]

PeerJ. 2018 Jul 3;6:e5115. doi: 10.7717/peerj.5115. eCollection 2018.

L

Honey reduces the metastatic characteristics of prostate cancer cell lines by promoting a loss of adhesion.

Abel SDA1, Dadhwal S2, Gamble AB2, Baird SK1.

Author information

1

Department of Pharmacology and Toxicology, University of Otago, Dunedin, New Zealand.

2

School of Pharmacy, University of Otago, Dunedin, New Zealand.

Abstract

Honey has been shown to have a range of therapeutic effects in humans, with anti-inflammatory and anti-bacterial effects among those previously characterised. Here, we examine the possibility of New Zealand thyme, manuka and honeydew honeys, and their major sugar and phenolic components, reducing the development of metastatic cancer. Their activity was examined in vitro, in PC3 and DU145 prostate cancer cell lines, through measuring the compounds' effects on the metastatic characteristics of migration, invasion and adhesion. First, the phenolic compounds gallic acid, caffeic acid, quercetin, kaempferol and chrysin were quantified in the honeys using high performance liquid chromatography, and found in nanomolar concentrations. In a Boyden chamber-based migration assay, non-toxic concentrations of thyme and honeydew honeys reduced cell migration by 20%, and all phenolic compounds except caffeic acid also lowered migration, although a mixture of only the sugars found in honey had no effect. All of the honeys, phenolics and the sugar-only mixture reduced invasive movement of cells through extracellular matrix by up to 75%. Most notably, each of the three honeys and the sugar-only mixture reduced cell adhesion to collagen I by 90%. With the exception of quercetin, phenolic compounds did not reduce adhesion. Therefore, honey and its sugar and phenolic components can lower the metastatic properties of cancer cells, and may do this by preventing effective cell adhesion to the extracellular matrix. The sugars and phenol compounds of honey are much more effective in combination than individually.

[gusgold]

That is the good news...the bad news is you have to consume 7 lbs of honey a day

[j-o-h-n in reply to gusgold]

It's ok if you're Winnie the Pooh (and Tigger too).

Good Luck, Good Health and Good Humor.

j-o-h-n Thursday 01/24/2019 6:18 PM EDT

[pjoshea13]

Honey is 36% glucose. Immediately available for a glucose spike & insulin response. At least with table sugar (sucrose) the glucose is bound to fructose. The glycemic index [GI] of sucrose is only 65, compared to 100 for glucose.

Honey is also 41% fructose - GI=19.

"the phenolic compounds gallic acid, caffeic acid, quercetin, kaempferol and chrysin" can be obtained from supplements without the sugar load.

-Patrick

(I wonder how many people believe that sugar feeds cancer but honey is somehow OK, because it's natural?)

[Graham49 in reply to pjoshea13]

I guess if you could take the sugar out it would be quite a good supplement?

[pjoshea13 in reply to Graham49]

How difficult could that be?

There are honey extract products for cosmetic-related use.

The polyphenol value of an extract would depend on the flowers that the bees have visited.

-Patrick

[elvismlv123 in reply to pjoshea13]

Thanks Patrick...Its a curious contradiction about sugar and honey...propolis does not seem to have the sugar but Manuka is similar at least from a taste test.You could get away from clover to manuka and maybe be better off. Manuka costs more. Blackstrap molasses can be looked at as well.

[Sxrxrnr1 in reply to elvismlv123]

It is well known that for those who have IBS driven by fructose malabsorption, that honey because of its high fructose content can exacerbate their IBS symptoms,,,primary demonstrated by intense diarrhea,,,somewhat as lactose malabsorption which is more common.

Many sufferers of IBS and their Gastrointestinal Docs have not a clue as to fructose and sorbitol as root cause of their IBS symptoms.

Google fructose malabsorption for more details if interested. Meanwhile just be aware if you choose to ingest honey and/or most fruits or any food or drink that contains high fructose corn syrup. One of the worst substances used by industry in America’s food supply. Banned in many countries by the way.

[pjoshea13 in reply to elvismlv123]

Propolis does not have sugar because it is not a food. It is a resinous caulking agent used to seal unwanted openings in the hive. "Pro polis" means "before the city".

-Patrick

[gusgold in reply to pjoshea13]

Patrick,

there is a program on Netflix that proves almost all the honey is cut and adulterated. Production is way down because of Bee colony collapse while consumption is way up

[GeorgeGlass in reply to pjoshea13]

Is there one product that has these items? I don't want to add any more individual supplements.

[elvismlv123]

Manuka honey is claimed to be the best..but I use bee propolis for periodontal disease.

I didnt know it could help prevent mets in pca. Thanks for the insight. I think essential oils do the same. Reason is they are used for perio disease too.

[elvismlv123]

Thanks bill

[Hidden]

The bottle lineup is too long as it is! Every time I close my kitchen window one of them invariably falls in the sink