Jevtana

[MsHope]

Once again I am asking for any information that can be provided from this great group.

Would appreciate any information for Jevtana treatment.

At doctor's appt yesterday, my husband's hemoglobin had decreased to 7.6 and he had to have a blood transfusion. His Alkaline Phosphatase went up again.

He will start on Jevtana on June 20th. We are hoping this will do him some good.

My husband's Oncologist sent an order 6 weeks ago for him to start  Pluvicto. The only treatment center in Houston. The Oncologist in Houston called last week and told us my husband  couldn't have Pluvicto treatment because his Hemoglobin (8.6) was too low, Then another person from treatment center in Houston called and said he could get treatment. So we don't know what is going on.

We contacted his Oncologist in Victoria, Tx. which has been treating him for over 5 years. The PA said they were not aware of the issue of Pluvicto treatment with low hemoglobin. Which they should!!! Then Pa starts talking about treating him with another chemotherapy called Jevtana instead of Pluvicto.  That was not even discussed with his Doctor at the last visit. His Oncologist insisted on him taking chemo using Taxotere which he took 6 rounds of treatment. It did not work as well as expected. This was so he would qualify for Pluvicto treatment.

Thank you in advance for any replies.

Would appreciate any replies regarding Pluvicto treatments and side effects.

Yesterday had follow up appointment with his oncologist to go over scan results.

Doctor said obviously the Docetaxel did work some but not enough.

Next treatment will be Pluvicto.

My husband had his first chemo treatment of 275ml Docetaxel (Taxotere) on 1/11/24 and his 6th and last treatment 4/21/24.

My husband had his PSMA PET/CT last week and overall it was good.

Right frontal skull SUV 5.3 previously 0.75, C3 SUV 22 previously 13.9, right clavicle 9.23 previously 23.6 clavicle 3.0 previously 13.0 left humeral head 32 previously 36.3 right humeral head 10.3 previously 18.6, sternum 21.2, previously 31, L1 25

previously 31.2, sacrum 24.3 previously 34.6, Left anterior trochanteric femoral activity SUV 24 previously 23.5 - the volume involved has increased.

Last month my husband's PSA decreased 1144 points to 586. This month it increased to 1658.968 NG/ML. 1072 point increase. This is difficult to believe the difference.

Thank you in advance for any information you can provide

[God_Loves_Me]

so many contents and post related to pluvicto side effects

healthunlocked.com/search/p...

Extreme fatigue, dry mouth, dry eyes and also recently news side effect is "Pulmonary"

healthunlocked.com/advanced...

I am sharing below links with you so you can better questions for your MO.

prostatecancer.news/2019/12...

[Cateydid]

Dear Ms Hope:

I saw one reply to your post. It appeared to describe a good many negative side affects to Pluvicto. Here are highlights of my post in March, summarizing our experience of the treatment:

He’s spent the last two years “living” in the recliner in the living room. Pneumonia 3 times: a collapsed lung, likely from one of a series of falls last spring. On oxygen PRN since June 2023.

Surgery to stretch the right lung was completed in November 2023. Steady improvement since then.

Finished 6th dose of Pluvicto in February 2024. PSA <.05! Bone mets and lung tumors shrunk. Radiologist reading report says successful treatment. Uptake in liver and spleen.

Side effects included a general feeling of malaise and extreme fatigue at about day 3 post-infusion. That’s it. No more or less pain than prior to treatment….just really tired. So he slept!!

We’re in our second week of vacation in Florida, where my Joe is sunning and swimming, biking, and hitting tennis balls!!!!

Three times over the last two years I was certain the end was near. Joe’s rebound is nothing short of miraculous!

Wishing you the very best outcome,

Catherine

[dhccpa in reply to Cateydid]

Great to hear good results!

[MsHope in reply to Cateydid]

Thanks so much for your reply. That is wonderful about your husband

[j-o-h-n in reply to MsHope]

Tell Joe......... take pics of the young ladies on the beach and post the pics here. This way we can enjoy the vacation too.

Good Luck, Good Health and Good Humor.

j-o-h-n

[Shorehousejam in reply to Cateydid]

Does he have any Germline Mutations or Genomic Mutations?

[Cateydid in reply to Shorehousejam]

Tests so far have not shown any mutations

[Shorehousejam in reply to Cateydid]

That’s why such a great response, from my queries pluvicto Lu 177 seems to be an utter disaster for hyper / hypo progression for people with mutations

[MsHope in reply to Shorehousejam]

I have no idea what mutations are/mean. His oncologist has never mentioned this. Where would that info be and what are the differences?

[Hidden]

My husband completed 4 rounds of Pluvicto, December 2023 - April 2024. Treatment stopped after 4 rounds as some areas of cancer were progressing. During the treatment time, scans showed that many areas of lymph nodes and bone mets declined significantly; prostate uptake shrunk significantly, etc. In these areas, the path reports described the results as "near resolved." However in some lymph nodes they saw growth, and a few new bone mets. So our view is Pluvicto had a significant positive impact but now time to throw something else at the cancer.

Side effects of treatment: Fatigue for 2-3 days. Nausea well-controlled with meds. Dry mouth began after second treatment; Biotene and sugarless candy helped. Overall the side effects were significantly easier to manage than chemo.

Benefits: In addition to the impact on tumor avidity, his pain declined significantly during this treatment, and the interim periods between treatment offered very positive quality of life.

[MsHope in reply to Hidden]

Thank you for your response

[Shorehousejam in reply to Hidden]

Does he have any Germline Mutations or Genomic Mutations?

[wvdmb]

My husband has had 2 Pluvicto treatments. The chemo didn't work very well for him either. After 2 treatments his PSA dropped from 95 to 16. He has low energy but is in no pain now.

[MsHope in reply to wvdmb]

Thanks so much for your reply. Praying your husband continues to do well

[wvdmb in reply to MsHope]

Praying for you and your husband as well.

[MsHope in reply to wvdmb]

I have read that you cannot be close to a person for a day after Pluvicto due to the radiation. To minimize radiation exposure to others, advise patients to limit close contact (less than 3 feet) with household contacts for 2 days. What info were you given regarding this. This is impossible to do, since we have to drive to Houston and be in truck together. There is no way to be less then 3 feet.

[wvdmb in reply to MsHope]

We have a SUV. I drive him home. He sits in the back of the SUV opposite me. We have only one bathroom so he is supposed to flush twice after each use. I wash our clothes separately including bedding and towels for about 7 days just to be on the safe side and wear plastic gloves when cleaning the bathroom. Does your truck have a back seat?

[MsHope in reply to wvdmb]

Thanks for your reply. We have a F250 Ram Truck and it does have a back seat, but not 3ft away from front driver seat. Do you still sleep in same bed after treatment. Also we have a dog and he always sits with my husband in recliner.

[wvdmb in reply to MsHope]

We do not sleep together after his treatment and it would be best for your dog not to be that close to him. Our SUV is not 3 feet apart but it is the best we can do.

[Shorehousejam in reply to wvdmb]

Does he have any Germline Mutations or Genomic Mutations?

[wvdmb in reply to Shorehousejam]

Not that we are aware of.

[MsHope in reply to wvdmb]

How long did it take for your husband to get approved for Pluvicto and start treatments? I has been over 2 weeks since my husbands Onocologist advised him that he was going to get him on Pluvicto.

[wvdmb in reply to MsHope]

I am thinking it was about 3 weeks but after approval it was almost a month before treatment could begin.

[MsHope in reply to wvdmb]

Thank you so much for your reply, I appreciate it

[chipspesto]

I have completed six Pluvicto treatments with good results, and am looking forward to better outcomes than chemo. Each person reacts differently to any treatment. Below video might help your understanding.

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youtube.com/watch?v=JoJomAC...(Not working as expected?)

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Best to you

[j-o-h-n]

There are tons and more tons of member's reactions from Pluvicto treatments in the H.U. history file. You may wish to peruse them.... Hang Tough!

Good Luck, Good Health and Good Humor.

j-o-h-n

[diatom]

finished one treatment session. Start second dose June 4th. So far only fatigue.

[Neathuh1]

Hi. Just completed my 6th Pluvicto infusion 2 weeks ago. My side effects were very dry mouth, intermittent diarrhea and a noticeable loss of appetite, which was appreciated. The dry mouth has been the most uncomfortable but overall it sure beats the alternative. I’m glad to have had the opportunity to receive the treatments and the initial scans show my mets are “resolving”. Good luck to your hubby and God bless!

[MsHope in reply to Neathuh1]

Did you have to isolate yourself from other family members after each treatment?

[Neathuh1 in reply to MsHope]

Yes. I slept in the guest room and we kept three feet apart unless we were just passing each other quickly. No hugs or kisses for three days. That was tough but it passed quickly and our friends had fun joking about my glowing personality.

Again, God speed to you both.

[God_Loves_Me in reply to Neathuh1]

Does he have any Germline Mutations or Genomic Mutations?