Some one asked this previously but there was no definitive answer. Now that Pluvicto is becoming more common others may have gotten an opinion from experienced providers. My husband finally got his first Pluvicto last week and I put his Xgeva on hold just in case. I will ask in Thursday upcoming telehealth visit but would appreciate info from the smart people here.
Thoughts? Thanks.
Why did he stop Xgeva? When Xofigo (Ra 223) is used to treat bone metastases along with anti androgens they recommend to continue with bone agents.
He had one Xgeva treatment about 90 days ago and it’s supposed to be every 90 days.
His Pluvicto kept getting delayed until 6/21/22 when he finally received it. His second Pluvicto is scheduled for August 3.
I would do the opposite. Xgeva and Zometa prevented fractures when they tried combining Xofigo and abiraterone.
With Xofigo it is100% that you need bone medication. Professor Joshua explained that for Xofigo. I don't know for Pluvicto, but I will ask them what they think here in Sydney about having a bone medication parallel with Pluvicto.
I called Dr Luke’s office. They said they have not held Xgeva for Pluvicto.
Agree. Best not to stop the Xgeva. I had Lu-PSMA last month and not advised to discontinue it. It can be problematic to stop. Bone loss can rebound quickly when stopping it. Good luck to you both.
Pluvicto and PSA 
3rd Pluvicto update
Pluvicto and a port
Pluvicto 
