I've heard about metabolomics only recently while listening to a Dr Berg podcast. In short, if I understood correctly, it differs from regular blood tests by looking for the concentration of things (like amino acids, minerals, polyphenol, etc...) within your cells rather than the concentration in your blood.
For example a blood test might say that your calcium, potassium, choline, uric acid, vitamin D, and other things are within the norms. But a metabolomic test might reveal that there is no vitamin D in your mitochondria's environment (which can happen with some diseases).
I found this interesting so today I started to look into this. I've put down two links from NIH that talk about metabolomics overall but this next one here talks about it as a way to determine the off of surving prostate cancer: bmcmedicine.biomedcentral.c...
Just thought of asking Bing's Copilot AI about it. I asked "Can metabolomics help in dealing with prostate cancer?"
The AI's answer was:
Metabolomics, which involves analyzing a large number of low molecular weight compounds (metabolites) in biofluids, can indeed provide valuable insights into prostate cancer. Here are some relevant findings:
Identification of Metabolites Associated with Prostate Cancer Risk:
A study conducted in the Northern Sweden Health and Disease Study investigated the association between plasma metabolite concentrations and prostate cancer risk.
Lysophosphatidylcholines (LPCs) were positively associated with overall prostate cancer risk, especially LPC C17:0 in older subjects.
For aggressive prostate cancer, positive associations were observed with several glycerophospholipids (LPC C17:0, LPC C20:3, LPC C20:4, PC ae C38:3, PC ae C38:4, and PC ae C40:2).
Inverse associations were found with acylcarnitine C18:2.
These associations were stronger in case-controls with normal glucose tolerance1.
High-Throughput Metabolomics for Biomarker Discovery:
High-throughput metabolomics, which analyzes the entire metabolic profile of a biological system, has been applied to prostate cancer research.
Advances in liquid chromatography-tandem mass spectrometry technology have enabled the identification of metabolic alterations in prostate cancer2.
Vitamins, Metabolomics, and Prostate Cancer:
Metabolomic profiling has the potential to discover molecular species relevant to prostate cancer etiology, early detection, and prevention.
It may also help elucidate the biological mechanisms through which vitamins influence prostate cancer risk3.
In summary, metabolomics can aid in identifying novel risk factors, understanding disease aggressiveness, and potentially guiding personalized approaches in managing prostate cancer. However, further research is needed to fully harness its potential.
"Serum metabolomic analysis of men on a low-carbohydrate diet for biochemically recurrent prostate cancer reveals the potential role of ketogenesis to slow tumor growth: a secondary analysis of the CAPS2 diet trial" [1]
Bottom line: Low-carb diet may lenghthen PSADT {PSA doubling time}.
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Interesting. Too bad I can't add the low-carb diet to my set of tools since I am already an adept of it and my PSA doubling time doesn't appear slowed in the least. Though in my case, maybe it is offset by a quicker doubling time due to my BRAC2 mutated genes.
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Yes, Vitamin D again - but not specifically PCa.
Vitamin D and PCa mortality risk. 
Familiarity with Apalutamide Effectiveness, Costs?
