SPLASH Study using Lu-PNT2002 PSMA after second line hormonal treatment

[dadsdrdawn]

My dad is ready to sign over to the SPLASH PSMA study.

He is 87 and seems 70.

Was diagnosed 16 years ago with advanced prostate cancer and has done ADT, Erleada, and the cancer has spread to his spine, and lymph nodes 2 years ago.

He Loves life, is very active, very intelletually sharp, adventurous, golfs 3 X weekly, builds things, does projects and still consults for architects.

My mother is 86, they just got back from 2 weeks in Ireland, AND came back with Covid and were sick for 5 days.

My dad was not approved for the Lutetium medication as he has not had chemo.

His biggest issues are weight loss, chronic phlegm, and intermittent nausea. He is already a slim man that never stopped to eat due to being always busy.

My question is that I would LOVE any input on men that are doing this treatment.

Side effects?

Advice?

Support...anything to ask the doctor before he starts...or any input from caregivers.

Blessings to you all,

Dawn

[tango65]

I had Lu 177 PSMA treatment in 2016. I had several lymph nodes metastases. I required only one treatment. The side effects were very mild. Fatigue for less than 24 hours, some edema easily controlled, no problems with the salivary glands.

My understanding is that major adverse events happen when there is diffuse infiltration of the bone marrow (the PSMA PET/CT will show if it is present).

With diffuse infiltration of the bone marrow (a lot of bone mets) the Lu 177 PSMA may affect the normal bone marrow that is left causing problems with all the blood cells lines. If there are 4 or 6 treatments the salivary glands may be affected but they may recover after ending the treatments.

Lu 177 PSMA treatment is as effective as chemo and it treats the cancer anywhere in the body.

[dadsdrdawn in reply to tango65]

Thank you for sharing this information - Wishing you many blessings and years of health.

Dawn

[tango65 in reply to dadsdrdawn]

Thanks,

I wish you the best of luck with the treatment,.!!

[dadsdrdawn in reply to tango65]

Can you tell me what state your body was in when you did this treatment, why you only did one? Any questions that my dad can ask his doctor, or things to look out for (if he qualifies) will be greatly appreciated. Have a blessed holiday season!

[tango65]

I was in pretty good shape (72 years old at that time) , just starting ADT after they found the mets, 14 years after initial diagnosis and 13 years after first biochemical recurrence and 11 years after second recurrence post prostate fossa and whole pelvis radiation.

The mets were multiple lymph nodes from the pelvis (mesorectal ) to the retroperitoneum well above the aorta bifurcation.

I had only one treatment because after the first treatment all the mets became PSMA negative.

This was confirmed by 5 PSMA PET/CTs done between December 2016 up to November 2021.

New mets appeared in February 2022 .None of the mets treated with Lu 177 PSMA in 2016 appeared in subsequent PSMA PET/CTs, diagnostic CT scans, diagnostic MRIs and FDG PET/CTs.

I would ask about the SUV of the lesions which are prognostic of the efficacy of the treatment,

If he has many bone mets, I would ask if there is a diffuse infiltration of the bone marrow which could be a contra indication for Lu 177 PSMA treatment.

I would also ask about dose of Lu 177 PSMA, interval between treatments and frequency of PSMA PET/CTs to check efficacy of the treatment and about the criteria to stop treatments.

I hope he qualifies and I wish you the best of luck with the treatments.

[dadsdrdawn in reply to tango65]

Thank you so much for your responses...they are greatly appreciated and I wish you a lifetime of health and many blessings!