I was treated with 6 rounds of docetaxel in 2017/2018 when I was HSPC and I responded exceptionally well. I have been CRPC since 2022 and have tried abiraterone and Radium 223 (Xofigo). I just completed 7 rounds of docetaxel again and PSA went from 105 to 3.1 after 4 rounds then started doubling. Now I will be switching to cabazitaxel for another 6 to 10 rounds.
Has anyone switched and had any luck?
Apparently here in Canada they don't offer Pluvicto as SOC yet. I am running out of options.
It's my understanding that the BC government has recently put more money into the Lu-177 trial in Vancouver so that it can continue accepting patients. Apparently it is cheaper to offer a drug as part of a trial compared to listing it as a standard therapy. At some point they will need to list it as SOC. Hopefully you will be able to get into the Vancouver trial if the cabazitaxel is not effective. Good luck with your treatment.
I was informed by my oncologist that I can’t get into the trial because I have had chemo before.
I'm confused, I thought they only wanted people that had already had chemo? Am I missing something. I'm also in BC, on Salt Spring Island.
Here is the listing for the trial. It doesn't say that prior docetaxel will exclude you.
I know this is what I was just told by my oncologist. I am going to get a referral to Vancouver and see what they can do.
You could also reach out now to the contacts for the trial in Vancouver and confirm that your prior chemo does not exclude you : clinicaltrials.gov/study/NC...
If you are looking to just lower the PSA, try Fenbendazole. I did and lowered mine from 46.5 to 6 in 3 weeks.
We're you also using ADT?
I am also using Lupron
I also see, after reading about the clinical trials of ivermectin, that if I had used this product with my chemo, I would have enhanced the kill ratio of the chemo.
Do you have any references that support what you say about ivermectin?
When I became castrate-resistance, I was started on abiraterone and cabazitaxel. It worked very well for me. Last cabazitaxel infusion was three years ago. I am still on quarterly Lupron and daily abiraterone, and my PSA has been at or near 0.01 for over two years now. Regular CT scans and bone scans have shown no progression.
My experience was that the side effects from cabazitaxel came on sooner and hit harder. The only side effect that was less than when I had docetaxel was hair loss.
It wasn't pleasant, but I got through it, and it was worthwhile.
Your story is very much like my husbands. I would appreciate any input you have to his recent doctors appt. Here is my post: Yesterday was very disappointing as my husbands PSA increased again by 183 points, last month his PSA was 1546 and now it is 1730. All his other CBC results were good. His Alkaline Phosphatase increased 6 points, last month 127 and now 133 but still in range of 40-150. Questioned why PSA was increasing each month. Only explanation was maybe his 6 month Lupron injection had worn off. Yesterday was his time to get Lupron injection. I have a hard time believing that is the cause. He feels good, has gained weight and no significant pain since starting chemo. I asked about the post chemotherapy syndrome and was told that was not the cause, as it only last the first couple of chemo treatments. The only side effect he has had with docetaxel is some hair loss.
His PSA went down after first chemo treatment and has been rising ever since.
Apr 04, 2024
1730.360 NG/ML
Mar 14, 2024
1546.711 NG/ML
Feb 22, 2024
1377.071 NG/ML
Feb 01, 2024
1307.241 NG/ML
Jan 18, 2024
1688.624 NG/ML
Doctor wants him to have another PMSAT scan. Ask it that would tell us why PSA is increasing and was told it would show any active cancer cells. That didn't answer our question. Obviously there are active cancer cells since his PSA is increasing. We will decide on that after next chemo treatment.
Any insight to this issue would greatly be appreciated.
Could you reach Seattle??
I was able to get a referral to BC Cancer in Vancouver where they have the trial for Lu-177.
Seattle is close and could be an option if they have an open trial. I see there is a trial for PT-112. Not sure if this would work for me but might be worth looking into.
Chemo #4 update
When to move on to next treatment? 
Xtandi the right thing?
In need of advise for my father
