Chemo

[Fight11]

My husband has had 6 rounds of Docetaxel, 3 rounds of jentava and now two rounds of Jentava along with Carboplatin. None have even touched the psa and some progression on the scans. This is taking a huge toll. He has been on Zytiga, Lynparza, Keytruda now the chemo. Just asking opinions. Do any of you think that maybe Xtandi could work? Could Darolutamide also be a possibility or is this drug only used with no Mets? He has to wait a couple more months for any trial due to blood clots. Could really use some feedback. Thank you

[lcfcpolo]

Wait for some replies from the experts here. However, I can say that I had blood clots and so far Xtandi has worked for me.Good luck.

[Fight11 in reply to lcfcpolo]

Did you fail chemo then go onto Xtandi? Also have you ever been on Zytiga?

[lcfcpolo in reply to Fight11]

No chemo and no Zytiga. Xtandi was my first treatment along with ADT.

[Javelin18]

Damn, so sorry to hear he isn't getting the results you want. What a fighter. I can only imagine the toll that accumulates over the treatments.

I found little benefit from abiraterone,and haven't tried enzalutamide I didn't expect much help from aberaterone, since my testosterone was <6ng/ml prior to taking it. I think it's primary method of action is to block testosterone production. Enzalutamide blocks the use of testosterone within the cancer cell, so it might give better results.

I've seen a lot of anecdotal posts saying that enzalutamide is effective alone and in combination with other treatments.

[NotAlwaysSunshine]

What was the reason that your physician did not try Provenge? Can you retry the Docetaxel?? When do you go back to the oncologist?? I hope you find something soon!!!

[Tall_Allen]

Why not try Xtandi? Nubeqa is only approved for non-metastatic CRPC. Erleada is only approved for that and for metastatic HSPC. However, I've seen some MOs get approval for both of them anyway. I don't know if any of them are better than any others. Anecdotally, Erleada seems more powerful but has more side effects.

[HopingForTheBest1]

Is he now taking Eliquis, an effective med for clots?

[Fight11 in reply to HopingForTheBest1]

Yes

[Curehunter]

Hold tight Fight11. It's hard but don't lose hope. If he is accepted on clinical trials there is still hope. I was DX a few months earlier in Feb and Abiraterone didn't work at all, ADT worked 3 months before I became castrate resistant. I was BRAC2 which worked for 3 months before first PSA rise but managed to squeeze 7 months out. May be worth getting some testing done. How is his PSA and does he have soft tissue disease.

[Fight11 in reply to Curehunter]

His psa just keeps trending up. It’s 211 and not softy tissue disease in bones only. Thank God.

[CAMPSOUPS]

As I've said before you and him have been thru a lot in a short period of time. I guess hold tight, hang in there are an understatement but I offer that anyway.

You question about Xtandi use it seems overall has been confirmed by many here to be worth it. No harm at all in trying. I also thought that chemo re-sensitizes cells so that Xtandi is effective in cases when it otherwise hadn't been.