PSA doubled in last 30 days after 4 m... - Advanced Prostate...

Advanced Prostate Cancer

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PSA doubled in last 30 days after 4 months stable since Provenge. What's next?

SViking profile image
10 Replies

Update: PSA remained roughly 1.7 to 1.8 for last 4 months after Provenge but yesterday's 30-day PSA test revealed a jump to 3.190 so something is growing quick. I have been off of all ADT since finishing fourth LU-177 injection five months ago and one SBRT treatment 4 months ago.

After LU-177, PSA had been climbing quick until leveling off at 1.77 even as testosterone slowly returned.

New PSMA scan scheduled for next week but I have a feeling tumors won't show up.

What's next?

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SViking
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cesces profile image
cesces

Take another PSA test just for the heck of it.

Do that before taking a PSMA.

SViking profile image
SViking in reply tocesces

Thank you. I’m not sure what another PSA test will reveal. The day before SBRT my PSA was 2.2 and it only went down to roughly 1.80 for the last several months. This made me assume that those two tumors that showed up on my PSMA scan were not the only tumors, just the ones visible.

So basically, whatever cancer is left is either a large amount of micro metastasis or not PSMA avid. That’s why I suspect the PSMA test next week might not reveal any new tumors even though they exist. If that was the case what other type of scan could I try?

cesanon profile image
cesanon in reply toSViking

After a second verifying PSA test, along with the psma scan you need an FGD scan to look for cancer that the psma scan won't light up.

And while you are at it maybe look for another care team while seeking a few second opinions.

SViking profile image
SViking in reply tocesanon

Thanks. Is the purpose of another PSA test to determine if the previous test was incorrect?

cesanon profile image
cesanon in reply toSViking

Why not. See which test is the anomaly. Simple, cheap and quick. Something you cannot say about a psma scan.

God_Loves_Me profile image
God_Loves_Me

time for Xtandi or apalutamide or darolutamide. Start immediately

rick8637 profile image
rick8637

I had a similar increase this month. After 6 months at 1.4 it went to 2.5. I am on orgovyx and ubeqa currently. I am wondering if physical condition at the time can play a part. I was very busy and anxious with work related issues and had spent some time snowmobiling which is serious exercise. Plus I was having slight UTI issue which since went away after the PSA test(of course). all these things can have an effect on psa readings. I am gonna have a retest under normal conditions and I think you should too before you adjust care.

SViking profile image
SViking in reply torick8637

The only thing I did different was doing a 4-day water-only fast. I've been training like crazy my whole life.

Worked_the_World profile image
Worked_the_World

You understand your condition better than I. Keep me in your loop brother.

SViking profile image
SViking in reply toWorked_the_World

Will do

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