Metastatic Prostate Cancer Resisting to Treatments

[Aliannado]

My dad (55) is diagnosed with metastatic prostate cancer that spread to his bones (mainly pelvic and ribs). He was put on Lupron, Docetaxel and Nubeqa. He made improvements in the first 4 months. PSA dropped to almost 0. However, once he started radiation and completed that, his conditions were getting worse. His chemo and medication are no longer working so the oncologist is switching to another chemo. It doesn't look like it is working after 3 cycles. His PSA went up from 4 to 31.

I'm just seeking out in the community if there are any other options at this point or what the next steps in terms of expectations. It seems like his condition is resisting the treatments that worked before.

We are located in Quebec, Canada.

Thank you.

[Tall_Allen]

Some of the combos with Xofigo may work for him:

prostatecancer.news/2021/02...

[Artsyogaman]

Hi, I was in a similar situation. I got on a clinical trial at Sloan Kettering and my tumors have shrunk (nothing else in Lymph nodes), receding in bones, PSA down to .035. It sounds as if your dad meets the requirements for getting on this trial. Here is the information on the treatment (immunotherapy.) I wish you and your dad the best.--James Williams, Brooklyn, NY

Clinical Trial

[DonV in reply to Artsyogaman]

Can you give me more information on your treatment plan @ Sloan? Most of your attachment did not come thru.

Thanks,

Don

[Artsyogaman in reply to DonV]

After Lupron, Abiraterone, Prednisone followed by Radiation Seed implant and external radiation, I was fine for 2 years. PSA began to shoot up and my urologist suggested I consult an oncologist. A biopsy and PET scan showed prostate cancer cells had migrated to bones and lymph nodes.

I went onto a clinical trial at Sloan Kettering in December of 2022. It was a new drug that was delivered by injections to the stomach. After 3 injections over a period of several days, I was admitted for 1 week to the hospital for increasing dosages to determine the maximum dosage my body would tolerate with minimal side effects. I get 4 injections totaling 800, 200 in each needle (ccs, I think.)

Thereafter, I went weekly for the 4 injections for several months with Nuclear Scans and Bone Scans every 12 weeks. PSA went to non-detectable, and scans showed the elimination of cancer in the lymph nodes and decreasing cancer in the bones.

I now go once every 3 weeks for injections. I experience minimal side effects.

My understanding of the therapy is that the drug, JNJ-78278343 finds and targets the cancer cells and my immune system attacks and kills the cancer cells. To qualify for this trial, one has had to have had metastatic prostate cancer that stopped responding to other treatments.

When I went on the trial in Dec of 2022, I was only the 3rd patient at Sloane Kettering and there were only about 65 patients nationwide on the trial. All patients at that point were put directly on the drug. No placebos at that point.

My doctors are very happy about the success so far with non-detectable PSA and decreasing tumors. The side effects, at first, resulted in headaches and flu-like symptoms. Now, I hardly experience any side effects.

To learn more about this drug, I suggest you google it. Here is my first google hit:

“anti-KLK2/CD3 bispecific antibody JNJ-78278343

A T-cell-redirecting agent and humanized immunoglobulin (Ig) G1 bispecific antibody targeting both human kallikrein-2 (hK2; KLK2) expressed on tumor cells and the CD3 receptor complex expressed on T cells, with potential immunomodulating and antineoplastic activities. Upon subcutaneous administration, anti-KLK2/CD3 bispecific antibody JNJ-78278343 binds to both CD3 on T cells and KLK2 on KLK2-expressing tumor cells. The resulting cross-linkage activates and redirects T cells to KLK2-expressing tumor cells. This results in T-cell-mediated lysis of KLK2-expressing tumor cells. KLK2 is overexpressed in certain tumors, including prostate adenocarcinoma.”

My understanding is that there are several hospitals in the US that are still accepting patients. Sloan Kettering has been a life saver for me.

After almost 2 years of treatment, I am in good health. At age 81, I am able to hike, camp, do Tai-Chi and Aerobic Dance. This summer, I went on a Peace Walk with Veterans for Peace from Ogunquit, Maine to Washington, DC leaving the walk every 3 weeks to return to NY for treatment and rejoining the walk

Let me know if you have any more questions

[street-air in reply to Artsyogaman]

this is a very interesting post, thanks

[j-o-h-n in reply to Artsyogaman]

Holy Shit............ seems like everyone is 81 years old............... Making me feel like an old Dog @ 88 in two weeks..... (p.s and you from Bklyn and me originally from the Bronx now in Queens)....And being treated at Sloan.....68th and First - Kimmel center.

Good Luck, Good Health and Good Humor.

j-o-h-n

[Mgtd in reply to j-o-h-n]

Now I think I understand. Do you get your material from the “Jimmy” Kimmel center. That explains why it is really sick!

[j-o-h-n in reply to Mgtd]

OMG you're the only one that picked up on that.

Note: Both James and I love a good fresh Jewish Rye bread with a fair amount of Kimmel. My Fist bump to you!

Good Luck, Good Health and Good Humor.

j-o-h-n