Rising PSA after starting Zytiga - Pr... - Advanced Prostate...

Advanced Prostate Cancer

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Rising PSA after starting Zytiga - Prednisone - Eligard

38 Replies

Good morning Warriors:

My MO added Zytiga and Prednisone , in addition to Eligard, to my fight on November 7th when my PSA hit 4.5. My next PSA on December 6th was 7.8 and my PSA from yesterday, 12/29, was 10.1. Obviously freaked out - been fighting this beast for 18 years. Feel great - no noticeable side effects other than hot flashes that are tolerable. Does this mean the Zytiga is NOT working. Love to hear your thoughts.

Thank you.

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38 Replies
Pleroma profile image
Pleroma

The numbers suggest it may not be working - but I say that from a purely anecdotal opinion.

A scan at this point would be the best judge of tumor progression.

in reply toPleroma

Thanks so much for your input.Appreciate your help

GoBucks profile image
GoBucks

I know little compared to the smart folks who will hopefully answer later. It seems 7 weeks is not a long time to try something. Your question while perfectly fine here should be directed to your MO. If your MO is not part of a Center of Excellence(or even if so) it may be time for a 2nd set of eyes.

in reply toGoBucks

Thanks so much go bucksMy MO is at Mayo Phoenix and I did this PSA on my own outside of the Mayo clinic just because I was so curious. I see him next week and have another PSA thank you so much for your input

Tall_Allen profile image
Tall_Allen

You can discuss switching to dexamethasone. A bone scan/CT will tell you if there is any real progression.

in reply toTall_Allen

Thanks so much ta. I have scans coming up in a couple weeks. My last scans three months ago showed only marginal growth of my bone mets and thank God I have no soft tissue mets. Is dexamethasone like xytiga.Always appreciate your very

Frank input your knowledge is amazing.

Thank you

Tall_Allen profile image
Tall_Allen in reply to

Sorry, I should have explained. Dexamethasone is a corticosteroid that would be taken instead of prednisone. It replaces what Zytiga takes away. It is taken with Zytiga.

in reply toTall_Allen

Oh thanks - do you think that would increase the efficiency of the Zytiga?

Tall_Allen profile image
Tall_Allen in reply to

It might.

in reply toTall_Allen

Thanks TA

dhccpa profile image
dhccpa in reply toTall_Allen

Is there a reason to do a bone scan or CT scan for bone mets if you can do a PET scan instead?

in reply todhccpa

Idohaveabout8visiblebonemets.Had them for3years. Scheduledfor CT and bone scan in 2 weeks.Thanks so much.

Tall_Allen profile image
Tall_Allen in reply todhccpa

The reason is to track progression. Bone scan/CT are cheap, so it is a better tracking tool. If you were to switch from a bone scan/CT to a PET/CT scan in midstream, is the increase in metastases due to progression or a more sensitive scan?

dhccpa profile image
dhccpa in reply toTall_Allen

Thanks I've had them all at least twice, including one Pet Bone Scan and two (most recent) Axumin Pet scans. So any advantage at all now to bone scan or CT scan?

Tall_Allen profile image
Tall_Allen in reply todhccpa

You have a scan to potentially change treatment. I have no idea what you had before or after each treatment, so I can't comment.

dhccpa profile image
dhccpa in reply toTall_Allen

Lupron only since the beginning. All scans have been simply monitoring.

Tall_Allen profile image
Tall_Allen in reply todhccpa

Then why did you have the scans? PSA progression? Symptoms?

dhccpa profile image
dhccpa in reply toTall_Allen

It was never explained at each stage, but at one point I was being assessed as a candidate for radiation. That RO ran two CTs, an MRI, and then a PET bone scan. A year later je ran an Axumin PET. Then my PSA rose this past summer and my local MO ran another Axumin. However, PSA soon dropped in half back to where it was.

My original question was simply why run a CT or a bone scan if you can run a PET (assume your carrier will pay, as mine always have)?

Tall_Allen profile image
Tall_Allen in reply todhccpa

It's not a general question - it may be a good idea for you b/c you have baselines, but a bad idea for someone else. I wonder if your insurance will refuse to pay for more Axumin - be sure to get pre-authorization.

in reply toTall_Allen

Hi TAWhat is axumim?

Thanks

Tall_Allen profile image
Tall_Allen in reply to

The article explains the different types

dhccpa profile image
dhccpa in reply toTall_Allen

Oh yes--pre-authorization is a must. Recently my doc's medical center failed to renew a pre-authorization for an Xgeva shot and they had to eat the cost.

As for Axumin Pet, Florida Blue Cross only paid $3,500 for the last one. I'll be on Medicare for the next one.

in reply todhccpa

I am on regular Medicare and a great secondary insurance. Why should I ask for a pet scan I don't know anything about itThanks so much

dhccpa profile image
dhccpa in reply to

I have never asked for a particular scan at a particular time. The docs do that. They usually don't say why. I would say, though, that most seem to feel a PET is most accurate for assessing bone mets. That's my impression.

in reply todhccpa

Why is a pet scan better

Tall_Allen profile image
Tall_Allen in reply to

Here's some info:

prostatecancer.news/2016/12...

dhccpa profile image
dhccpa in reply to

I never actually said it was. I was asking, though, because the docs have given me that impression.

Magnus1964 profile image
Magnus1964

I don't know what other drugs you have been on but it may be time to switch to xtandi.

in reply toMagnus1964

Nothing but Eligard until November 7 when added Zytiga.Thanks Magnus

Zetabow profile image
Zetabow

I'm in a similar situation, the Radium223 stopped working after 4 rounds and my PSA jumped from 0.028 to 300, slowly at first then pretty fast once it hit 130, I had a PET scan which showed progression in Spine, Hips and Femurs, the pain was also increasing, Oncologist switched me to Zytiga start of Oct and within a few weeks the pain reduced and my PSA dropped down to 88, it was also the first time I had any pain relief since diagnosed 2 years ago. My Dec appointment now shows PSA increasing, now at 110 and pain levels have increased as well, it's very up/down, one moment the pain is so bad I can hardly walk then a week later it's almost gone, only to repeat the cycle of pain.

I'll see my Oncologist in 3 weeks, I hope he has a solution to get my PSA back under control. Having no experience in this situation I'm not sure what this means for me. How many options I have left and if they keep failing they way they are at the moment, how much time do I have before this cancer takes over completely, it always seems to find a way around my treatments.

The only thing he did was double the Prednisone to 20mg when I said the pain and fatigue was bad.

in reply toZetabow

Wow - Good luck - please keep us posted.Thanks

NevsMates profile image
NevsMates

I would stay on Zytiga a bit longer. I would add Avodart.

in reply toNevsMates

Ok - what does avodart do???

Bacana profile image
Bacana in reply toNevsMates

I’d also like to know the benefit of adding avodart to zytiga, hubby current takes Flomax and zytiga.

NevsMates profile image
NevsMates in reply toBacana

The possible reason why men do not get a longer result with Zytiga can be the issue with being ARV7 positive.Avodart may assist in countering.

Bacana profile image
Bacana in reply toNevsMates

Interesting, will ask urologist about switching, thanks!

Kevinski65 profile image
Kevinski65

Do u take supplements? If u don't do u want too? It's all anacdotal. If they move u to Xtandi u usually get to drop the steroid.

in reply toKevinski65

Hi Kevinski:No I do not take supplements..

The thing that confuses me is I I only have some hot flashes from the Eligard - no bad effects from the Zytiga and predisone. Still feel great - exercise, lift weights, walk and play golf. Not as much energy as 5 years ago. T is 7.

Frustrating.

Thanks....

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