Approved for Lynparza (Olaparib)

[Alvin735]

PSA is rising and Xtandi doesn't seem to be doing it anymore, so Dr. Sartor has me going on Lynparza probably starting at my next appointment in two weeks. If anyone has any advice as to side effects, time to take it, etc or any other advice, I would appreciate it. I know I used y'all's advice when on chemo and it helped quite a bit. Thanks

[Blair77]

Why did he choose that particular therapy?

[Alvin735 in reply to Blair77]

I've done about everything else at this point ... here is what I have on my "about me".

Diagnosed 4/12; PSA 177; G9 (5+4); some bone mets

Eligard + Casodex 4/12; Radiation 8/9/12 - 10/5/12

HT on and off since 2012

BRCA2 Gene; Provenge May-June 2018; PSA 2.0 6/21/18

Zytiga 8/18 - 3/19 PSA 2.24 3/19

4/19 started Bipolar androgen therapy (BAT) PSA 2.63

BAT failed 5/15/19 PSA 12.2; Active mets on C5 spine plus other places.

Started Docetaxel Carboplatin combo 5/22/19. PSA down to .8 Aug 2019; Chemo stopped after 4 infusions due to bad reactions and terrible skin rash. 9/19 - CT scan shows new met in lungs. Starting Xtandi 10/19 - did not qualify for the Vision Trial. PARP inhibitor next if Xtandi doesn't do it.

[Blair77 in reply to Alvin735]

I love that you have a doctor that keeps trying and that you do too! Light& love

[dougnola in reply to Alvin735]

Hey Alvin. I’m sending positive vibes. I’m still doing well on Zytiga and Lupron but I’ll be following you. I see Sartor too and he’s great. I also had a skin rash with carbo and taxotere combo. We thought it might have been the steroids but maybe it was the chemo combo. ✌️ dougnola

[Balsam01]

I would suggest searching this forum for "Olaparib" and you will get some answers.

[elainea53]

My husband was just taken off the olaparib trial at mda.

The doc now putting him on a radium treatment shot once a month for 6 months. Lots of bones mets.

This is at mdandersen but he get s injections at emory in Atlanta where we live. I hope it works for u. My husband not brca.

Where is dr sartor

Good luck

[Alvin735 in reply to elainea53]

Tulane Cancer Center in New Orleans, La

[vandy69]

I took Lynparza while under the care of Dr. Snuffy Myers. Guardant360 liquid biopsy revealed ATM defect which qualified me for Lynparza.

It worked for me for about 9 months before cancer found a workaround. Do not recall any significant SEs.

It is very expensive so make sure your insurance company will cover it.

Best Wishes. Never Give In.

Mark, Atlanta

[Alvin735 in reply to vandy69]

Thanks.

[elainea53]

Is this a trial.

My husband was in a lypanza trial. It did not work for him.