Adaptive dosing: very promising resul... - Advanced Prostate...

Advanced Prostate Cancer

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Adaptive dosing: very promising results with Enzalutamide + Lutetium

Maxone73 profile image
18 Replies

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Maxone73
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18 Replies
Rolphs profile image
Rolphs

Very encouraging that Enzo and Lut in various dosing extends survival. Especially for some hormone sensitive patients 2 doses can extend use of ADT. I will pass along to to MO.

Thanks!

Justfor_ profile image
Justfor_

Welcome to the club! Second year anniversary for me on Bicalutamide adaptive dosing.

lcfcpolo profile image
lcfcpolo

Brilliant video. Really helpful if you are still hormone sensitive or castrate resistance. Yet again the Aussies ahead of the curve here. Not even said thru my English gritted teeth.

Maxone73 profile image
Maxone73 in reply tolcfcpolo

G'day to you mate! 😜

lcfcpolo profile image
lcfcpolo in reply toMaxone73

Made me laugh out loud. Thanks for posting. This is something we should all watch.

Cactus297 profile image
Cactus297

Thank you!

swwags profile image
swwags

No Joke. for these old ears, closed captioning was required. I couldn't understand half of what she said.

Maxone73 profile image
Maxone73 in reply toswwags

I read the transcription below the video!! 😜

Cactus297 profile image
Cactus297

Are you following a vegan diet? I read your profile, but I wasn’t sure if you have gone totally vegan or not ….my son has gone primarily vegan and eats almost zero animal protein/products.

Thank you!

Maxone73 profile image
Maxone73 in reply toCactus297

Hi! Apart from some fish (mostly fresh water or fat fish...like salmon, trout,...) yes, completely vegan. But I think that the key is more related to simple carbs and fat sources rather than proteins. I eat pasta like once per week now (I am italian, this goes against nature! 😆) and instead of normal pasta I use a whole grain one. The only fat I use is extra virgin olive oil basically (but it has been like that for my whole life...and it did not spare me from PCa) and the one coming from the walnuts and seeds I eat. I am very careful with insulin spikes, as if I were diabetic.

Cactus297 profile image
Cactus297 in reply toMaxone73

Your diet is very similar to my son’s. He also uses only extra-virgin olive oil, and as you said it didn’t spare him from PC. Instead of pasta, he eats mostly different types of lentils and he makes his own miso soup. His exercise is hiking and he’s going on a 3+ hour hike today before we have our vegan Thanksgiving dinner. He also eats tofu. Today we are having shrimp with cocktail sauce, but he normally doesn’t eat much that isn’t vegan..I think your diets are quite similar! And healthy! Thanks for letting me know what your diet consists of and I will tell him today at Thanksgiving dinner.I am enjoying all your posts. I told my son about the possibility that soon PC could be treated much like HIV. 👌👏👏👏!

PS Are lentils a good choice? He eats a variety of them and buys them dry, and cooks them all himself from scratch.

Maxone73 profile image
Maxone73 in reply toCactus297

All legumes, even canned (but no added sugar!) are a great choice. I am going to add homemade water kefir as well. I want to keep my gut in shape to fight everything else that might happen. One fight at a time is enough, let’s concentrate on cancer!

Cactus297 profile image
Cactus297 in reply toMaxone73

Spot on! Thanks!

Ian99 profile image
Ian99

Thanks again for posting. This concept of adaptive dosing strikes me as a creative way of limiting toxicity. Am unsure how easily it could fit within the structure of a public health service, may require private treatment. Definitely worth considering.

Justfor_ profile image
Justfor_ in reply toIan99

Limiting toxicity is good, but not the strongest point in adaptive dosing. Control of the different cancerous clones is the prime benefit. In the mentioned study, Enzalutamide drives into extinction the majority of HS clones, hence, bringing into the surface the resistant ones which the Lutetium later takes care of. It does make sense although I follow a different approach. Keep the population of the HS clones low, but NOT extinct, so that the resistant ones have to fight against them for dominance.

Ian99 profile image
Ian99 in reply toJustfor_

Many thanks for this explanation.

GreenStreet profile image
GreenStreet

Thanks very much for posting. Really interesting and encouraging. However we wont be able to get this combo on NHS unfortunately and would need self funding

MikeMartin profile image
MikeMartin in reply toGreenStreet

Did they tell you the cost?

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